TL;DR: A 2026 rat and cell study in Journal of Materials Science: Materials in Medicine reported that an engineered VIN nanosystem shifted microglia toward an anti-inflammatory state and reduced ischemic-stroke infarct measures in MCAO rats. Key Findings CXCR4 increased 1.75-fold: Fe3O4 nanoparticle induction raised CXCR4 expression in bone-marrow mesenchymal stem cell membranes. A151 loading reached …
TL;DR: A 2026 medRxiv preprint found that a composite cerebral small vessel disease (cCSVD) score from routine T1 MRI predicted 3-month cognitive recovery after stroke better than any single small-vessel marker in a 65-person cohort. Key Findings Recovery window: The study analyzed 65 early subacute stroke survivors who completed baseline and 90-day follow-up visits. MRI …
TL;DR: A 2026 preprint in medRxiv used natural language processing (NLP) on Scottish CT and MRI reports to subtype stroke at scale, linking lobar intracerebral hemorrhage to higher later dementia risk and cortical ischemic stroke to higher early myocardial infarction risk. Key Findings 785,331 head scans: Researchers applied NLP to CT and MRI head-scan reports …
TL;DR: A 2026 preprint in medRxiv reported that an interpretable CatBoost machine-learning model predicted stroke-associated pneumonia after acute ischemic stroke bridging therapy with a test-set AUC of 0.932, with 7-day stroke severity and early inflammatory markers among the strongest contributors. Key Findings 135 stroke patients: The retrospective analysis included 135 acute ischemic stroke patients who …
TL;DR: A 2026 population-based matched cohort study in British Journal of Psychiatry found that risperidone use was associated with increased stroke risk, adjusted hazard ratio 1.28, while absolute stroke incidence was especially high in people with prior stroke or cardiovascular disease. Key Findings Matched dementia comparison: The analysis compared stroke risk among risperidone users and …
TL;DR: A 2026 medRxiv preprint found that nonverbal Theory of Mind (ToM), the ability to infer another person’s beliefs or perspective, varied in 44 adults with post-stroke aphasia and was more closely tied to vascular brain-health markers than to aphasia severity. Key Findings Study group: 44 adults with aphasia after mostly left-hemisphere stroke completed 2 …
TL;DR: A 2026 medRxiv preprint found that giving intravenous thrombolysis (IVT), a clot-dissolving drug treatment, before endovascular thrombectomy (EVT), a catheter procedure to remove a large brain clot, did not significantly improve 3-month recovery or increase bleeding risk in selected stroke patients treated 6 to 24 hours after symptoms began. Key Findings Registry cohort: The …
TL;DR: A 2026 medRxiv preprint linked post-stroke depressive symptoms to stroke damage in serotonin-transporter and acetylcholine-transporter weighted brain networks, suggesting depression risk after stroke may depend partly on which neurochemical circuits a lesion disrupts. Key Findings 435 stroke patients analyzed: Researchers combined two independent cohorts, Leipzig and Oxford, after exclusions for missing clinical variables and …
TL;DR: A 2026 study in the Journal of the American Heart Association followed 1,882 stroke-free women from the Framingham Heart Study for a median of 18 years and found that having three or more live births was associated with a reduced risk of clinical stroke and lower MRI markers of vascular brain injury — the …
Brain Age MRI Mapped Stroke Recovery in 501 Patients TL;DR: A Lancet Digital Health ENIGMA study found that larger stroke lesions made the damaged hemisphere look biologically older, while severe motor impairment was linked to younger-appearing contralesional networks, likely reflecting compensation. Key Findings 501 chronic stroke survivors: The ENIGMA Stroke Recovery Working Group dataset included …
