TL;DR: A 2026 post-hoc analysis in International Clinical Psychopharmacology found that lurasidone 40 mg/day improved all 5 Positive and Negative Syndrome Scale (PANSS) symptom domains in acute schizophrenia over 6 weeks, with the largest effect on positive symptoms and later improvement in negative symptoms. Key Findings 483 randomized patients: The JEWEL phase 3 trial assigned …
TL;DR: A 2026 biomarker analysis in Brain, Behavior, & Immunity – Health across antidepressant trials found that kynurenine pathway metabolites were elevated in inflammatory depression compared with non-inflammatory depression and healthy controls, while omega-3 polyunsaturated fatty acid treatment reduced several kynurenine pathway metabolites. Key Findings Study type: a combined analysis of two depression trials testing …
TL;DR: A 2026 mouse preprint in bioRxiv reported that small-molecule IGF1R inhibitors, drugs that block insulin-like growth factor 1 receptor signaling, protected several healthspan measures in aging mice, but the tested compounds also carried major safety and drug-development problems. Key Findings 150 aging mice: Researchers assigned 55-week-old C57BL/6 mice to control diet, PPP, or NVP-ADW742, …
TL;DR: A 2026 cross-sectional NHANES analysis in Depression and Anxiety found that urinary pyrethroid metabolite 3-PBA showed a dose-dependent association with depression, while female participants showed stronger associations for 3-PBA and 4F-3-PBA, while males showed sensitivity to DCBA in mixture models. Key Findings Study type: a survey-weighted analysis using self-reported pesticide exposure and urinary pesticide …
TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuations and external distress. Key Findings Study type: a home-recording study using bidirectional deep brain stimulation devices to monitor electrophysiology during depression recovery. …
TL;DR: A 2026 PTSD neuroimaging and language-analysis study in Neuropsychopharmacology found that hippocampal activity encoded specific semantic content of traumatic and neutral autobiographical memories, while greater hippocampal sensitivity to autobiographical semantic content related to higher PTSD symptom severity. Key Findings Study type: a study combining natural-language semantic quantification with brain activity during traumatic and neutral …
TL;DR: A 2026 Nature Communications study found that mouse hippocampal CA3 connectivity shifts from dense-random early wiring to sparse-structured adult wiring, with weaker single synapses that make memory-network output depend on coordinated input rather than one strong connection. Key Findings CA3 connectivity transforms from random to structured during postnatal development: Early in life (P7-8 mice) …
TL;DR: A 2026 preprint longitudinal cohort analysis in medRxiv found that later-born cohorts showed higher memory levels entering old age and slower rates of memory decline, while the projected 20-year cohort advantage at age 80 was large enough in the model to account for a reported 13% per-decade decline in dementia incidence. Key Findings Birth-cohort …
TL;DR: A 2026 Sex Roles study using NLSY97 data found that the gender friendship gap in best-friend closeness was driven mainly by white men, while Black men, Latino men, and women across groups reported more similar closeness after controls. Key Findings NLSY97 cohort: The study analyzed 1,765 young adults from the National Longitudinal Survey of …
TL;DR: A 2026 longitudinal analysis in the Journal of Affective Disorders tracked 635 older adults with new-onset loneliness and found that cognitive decline matched controls before loneliness began, then accelerated after onset, especially when loneliness persisted. Key Findings Pre-loneliness cognitive trajectories were identical: Before the first reported episode of loneliness, cognitive scores in 635 future-lonely …
