TL;DR: A 2026 rat study in Neuropsychopharmacology found that PACAP/PAC1 signaling in the lateral septum changed forced-swim coping, ACTH stress-hormone release, open-arm exploration, and grooming behavior. Key Findings Stress changed PACAP signals by brain region: Acute swim stress increased PACAP mRNA in the lateral septum, BNST, and basolateral amygdala, while chronic variable mild stress reduced …
TL;DR: A 2026 medRxiv preprint used quantitative multi-parametric MRI mapping in 245 BeLOVE participants and found that white matter hyperintensities had lower MTsat and R1 plus higher proton density, with nearby normal-appearing white matter also showing microstructural changes linked to MoCA, a brief cognitive screening score. Key Findings 245 MRI participants: The analysis used cerebral …
TL;DR: A 2026 medRxiv preprint found that giving intravenous thrombolysis (IVT), a clot-dissolving drug treatment, before endovascular thrombectomy (EVT), a catheter procedure to remove a large brain clot, did not significantly improve 3-month recovery or increase bleeding risk in selected stroke patients treated 6 to 24 hours after symptoms began. Key Findings Registry cohort: The …
TL;DR: A 2026 cross-sectional metabolomics study in Brain, Behavior, & Immunity – Health found that serum and cerebrospinal fluid (CSF) metabolite signatures differed in knee osteoarthritis and related to pain, fatigue, sleep, and pressure sensitivity, while CSF histamine and 3-hydroxyphenylacetic acid were associated with pain intensity and sleep disturbance. Key Findings Study type: a targeted …
TL;DR: A 2026 Psychological Medicine meta-analysis of 109 studies linked parental severe mental illness, especially schizophrenia and bipolar disorder, to lower cognitive performance in offspring across IQ, language, memory, executive function, and general cognition. Key Findings Scale: The review included 109 studies and 1,586,339 participants. Schizophrenia: Offspring of parents with schizophrenia had lower scores across …
TL;DR: A 2026 case-series study in Translational Psychiatry tested delayed-release oral acetate from apple cider vinegar capsules in 11 young adults taking psychotropic medications and found high adherence, no product-related adverse events, microbiome shifts, and metabolic improvement in 6 participants, but the uncontrolled design means the findings need placebo-controlled testing. Key Findings 11 completers: The …
TL;DR: A 2026 mouse study in Nature found that small-molecule glucagon-like peptide 1 receptor agonists (GLP-1RAs), obesity and diabetes drugs built around a glucose-linked hormone pathway, suppressed palatable-food intake through central amygdala neurons that lowered nucleus accumbens dopamine. Key Findings Humanized mouse model: Researchers engineered mice so small-molecule GLP-1 receptor agonists could be studied despite …
TL;DR: A 2026 study in The Journal of Neuroscience found that listening to consonant chord progressions while looking at a live partner increased functional near-infrared spectroscopy (fNIRS), a scalp blood-flow measure, in social brain systems. Key Findings Dyadic design: The study tested 20 participant pairs while both partners were recorded at the same time. Two …
TL;DR: A 2026 mouse study in Cell traced ketamine’s rapid antidepressant-like effect to mu-opioid receptors on somatostatin-positive interneurons in the medial prefrontal cortex. Low-dose multi-GPCR targeting reproduced ketamine-like effects in mice, but the exact three compound names were not listed in the public source material verified here. Key Findings Cell target: ketamine’s rapid mouse effect …
TL;DR: A 2025 rat study in The Journal of Neuroscience found that caudal granular insular cortex (CGIC) projections to primary somatosensory cortex (SI) were required for neuropathic pain behavior, while activating the same pathway produced allodynia, or pain from harmless touch, in healthy rats. Key Findings CGIC-to-SI projections are necessary for neuropathic pain: Multiweek chemogenetic …
