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TL;DR: In 149 people with memory problems or dementia, blood levels of some brain markers tracked spinal fluid levels well, but others did not match at all. Two common measures of a leaky blood-brain barrier also did not agree with each other. Key Findings Blo…
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TL;DR: A 2026 review in International Journal of Nanomedicine argued that depression nanomedicine should move beyond blood-brain-barrier delivery alone and be judged by target engagement, neuroimmune-barrier-plasticity effects, safety, manufacturability, and p…
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TL;DR: A 2026 study in Oncoscience reported that nitrosylcobalamin, a nitric-oxide-releasing vitamin B12 analog, crossed the blood-brain barrier in glioblastoma-bearing rats and accumulated in tumor tissue. Key Findings NO-Cbl defined: Nitrosylcobalamin is a c…
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TL;DR: A 2026 review in the Journal of Neuroinflammation argued that several parasitic infections may affect behavior and cognition through converging microbiota, immune, barrier, and glial pathways. Key Findings Protozoa and helminths reviewed: The review cov…
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TL;DR: A 2026 review in Advances in Clinical and Experimental Medicine argues that autoimmune mechanisms may explain a subset of drug-resistant focal epilepsy, especially when seizures persist despite standard antiseizure drugs and immune markers are present.…
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TL;DR: A 2026 study in Journal of Nanobiotechnology found that Angiopep-2-modified natural killer cell extracellular vesicles carried temozolomide across glioblastoma barriers, reduced mouse tumor bioluminescence, and extended median survival in an orthotopic…
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TL;DR: A 2026 preclinical study in the International Journal of Nanomedicine developed human umbilical cord mesenchymal stem cell membrane-coated PLGA nanoparticles to co-deliver doxorubicin and curcumin to glioblastoma models, improving tumor-cell uptake and…
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TL;DR: A 2026 rat and cell study in Journal of Materials Science: Materials in Medicine reported that an engineered VIN nanosystem shifted microglia toward an anti-inflammatory state and reduced ischemic-stroke infarct measures in MCAO rats. Key Findings CXCR4…
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TL;DR: A 2026 mouse study in Blood found that Thrombosomes, a freeze-dried platelet-derived blood product, reduced bleeding, vessel leak, inflammation, and blood-brain-barrier disruption after traumatic brain injury. Key Findings Thrombosomes were tested after…
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TL;DR: A 2026 Nature Methods paper described a self-localized ultrafast pencil beam that made volumetric multiphoton imaging faster and more stable, including 1-minute 3D scans of transferrin uptake in a live human blood-brain barrier model. Key Findings Optic…
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