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TL;DR: A 2026 review in Translational Psychiatry argues for a biologically meaningful inflammatory depression subgroup, with CRP, IL-6, TNF-alpha, glial activation, kynurenine metabolism, and synaptic plasticity linking immune signaling to symptoms and treatme…
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TL;DR: A 2025 human proteomics study in Molecular Metabolism found that about 10 days of medically supervised water-only fasting caused weight loss and lower circulating amyloid beta proteins, but also increased inflammatory and platelet-activation markers. Ke…
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TL;DR: A 2026 medRxiv preprint linked higher blood inflammatory markers with diffusion MRI signs of altered white-matter microstructure in 457 dementia-free middle-aged and older adults, especially for a combined cytokine score and orientation dispersion index…
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TL;DR: A 2026 biomarker analysis in Brain, Behavior, & Immunity – Health across antidepressant trials found that kynurenine pathway metabolites were elevated in inflammatory depression compared with non-inflammatory depression and healthy controls, while omega…
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TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health found that depression symptoms, alcohol use, and alcohol use disorder (AUD) symptoms were not associated with C-reactive protein (CRP), a blood inflammation marker, or a pro-inflammatory cytokine inde…
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A new study provides evidence that the psychedelic compound psilocybin has both immediate and lasting anti-inflammatory effects in healthy volunteers. The findings shed light on how psilocybin may improve mood, social behavior, and potentially treat depression…
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A new study published in Nature Medicine has identified two biological profiles, based on routine blood tests during COVID-19 hospitalization, that can predict patients’ risk of developing post-COVID brain fog months later. Key Facts: The study analyzed data f…
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