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TL;DR: A 2026 study in Oncoscience reported that nitrosylcobalamin, a nitric-oxide-releasing vitamin B12 analog, crossed the blood-brain barrier in glioblastoma-bearing rats and accumulated in tumor tissue. Key Findings NO-Cbl defined: Nitrosylcobalamin is a c…
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TL;DR: A 2026 Nature Communications study used long-read single-cell RNA sequencing to map full-length isoforms in glioblastoma and found tumor-specific transcripts that short-read methods often miss. Key Findings 27 GBM samples: Researchers profiled histologi…
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TL;DR: A 2026 study in Journal of Nanobiotechnology found that Angiopep-2-modified natural killer cell extracellular vesicles carried temozolomide across glioblastoma barriers, reduced mouse tumor bioluminescence, and extended median survival in an orthotopic…
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TL;DR: A 2026 preclinical study in the International Journal of Nanomedicine developed human umbilical cord mesenchymal stem cell membrane-coated PLGA nanoparticles to co-deliver doxorubicin and curcumin to glioblastoma models, improving tumor-cell uptake and…
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TL;DR: A 2026 systematic review and meta-analysis in Neurological Sciences found that ketogenic diet (KD), a very-low-carbohydrate diet designed to raise ketone fuel use, looked feasible and generally safe as an add-on strategy in glioblastoma (GBM), but the s…
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TL;DR: A 2026 analysis in Journal of Korean Medical Science identified PIK3CG, PRKCD, and TRIM22 as glioblastoma gene markers linked to worse survival and stronger immune-activity signals in IDH-wildtype tumors. Key Findings 12,041-gene screen: Researchers scr…
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TL;DR: A 2026 study in Neuron found that glioblastoma was not growing alone: reactive oligodendrocytes helped maintain glioma stem cells through CCL5/CCR5 signaling, and blocking that conversation slowed tumor growth in models. Key Findings CCL5/CCR5 showed th…
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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of…
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Brain tumors can take a major toll on mental health. New research provides important insights into the psychiatric symptoms that often accompany these devastating diseases. Key Facts: Around 27% of brain tumor patients experience psychiatric symptoms like depr…
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