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TL;DR: A 2026 mouse study in The Journal of Neuroscience found that the HIV-1 protein gp120 amplified pain signaling through α2δ-1-bound NMDA receptors in spinal excitatory neurons, and blocking that receptor coupling reversed pain-like hypersensitivity. Key F…
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TL;DR: A 2026 Nature study found that satellite glial cells can transfer mitochondria to sensory neurons, and blocking that transfer in mice promoted nerve degeneration and neuropathic pain. Key Findings 83.3% transfer: In mouse co-cultures, 83.3% of dorsal ro…
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TL;DR: A 2026 study in Journal of Pain Research described 3 adults with type I complex regional pain syndrome (CRPS), a severe neuropathic pain condition with sensory, autonomic, motor, and skin changes, whose pain scores improved after pregabalin and who were…
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TL;DR: A 2026 study in Journal of Pain Research found that spinal cord stimulation and dorsal root entry zone lesioning reduced pain for selected patients with refractory postherpetic neuralgia, but the evidence came from a 10-patient single-center series. Key…
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TL;DR: A 2025 rat study in The Journal of Neuroscience found that caudal granular insular cortex (CGIC) projections to primary somatosensory cortex (SI) were required for neuropathic pain behavior, while activating the same pathway produced allodynia, or pain…
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TL;DR: A 2026 review in Reviews in the Neurosciences argues that chemotherapy-induced peripheral neurotoxicity (CIPN), nerve injury from cancer treatment, can involve central nervous system changes that help explain chronic neuropathic pain and chemotherapy-re…
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