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TL;DR: A 2026 case study in Biomedical Reports described a 28-year-old woman with bipolar II disorder whose stable subclinical counting compulsion worsened and expanded into new obsessive-compulsive symptoms within 3 days of starting cariprazine, then returned…
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TL;DR: A 2026 study in Molecular Psychiatry found that radiofrequency capsulotomy and inferior thalamic peduncle deep brain stimulation were associated with the largest symptom improvements among surgical strategies for refractory obsessive-compulsive disorder…
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TL;DR: A 2026 trial in Journal of Psychopharmacology found that repeated supervised psilocybin sessions reduced Yale-Brown Obsessive Compulsive Scale (YBOCS) scores, a standard measure of obsession and compulsion severity, in 15 adults with OCD. Key Findings 7…
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TL;DR: A 2026 preprint in medRxiv found that deep brain stimulation for severe obsessive-compulsive disorder was followed by lower globus pallidus externus alpha-band activity in clinically responsive patients, suggesting a possible brain readout of sustained…
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TL;DR: A 2026 systematic review and meta-analysis in Acta Neuropsychiatrica found no clear evidence that parenteral clomipramine is better than oral clomipramine for depression or obsessive-compulsive disorder, with low or very low certainty across the main ra…
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Antidepressant treatment in OCD is linked to structural and functional brain changes, particularly in corticosubcortical areas, but these findings need further validation in larger, more homogeneous samples. Highlights: Antidepressant Use: Antidepressants, esp…
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Obsessive-compulsive disorder (OCD) is a chronic and debilitating mental health condition characterized by obsessive, anxiety-provoking thoughts and compulsive rituals aimed at reducing anxiety. Affecting 1-3% of adults worldwide, OCD often begins in childhood…
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A new case study provides initial evidence that transcranial direct current stimulation (tDCS) may be an effective treatment option for trichotillomania, also known as hair pulling disorder. The study tested an intensified, repeated tDCS protocol targeting the…
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Obsessive-compulsive disorder (OCD) is a complex neuropsychiatric illness impacting approximately 2% of the global population. The disorder is characterized by intrusive, irrational thoughts (obsessions) and repetitive behaviors (compulsions) that patients fee…
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Obsessive-compulsive disorder (OCD) is a challenging psychiatric illness affecting 2% of the population. While some patients respond to therapy and medications, others continue to suffer from severe, treatment-resistant symptoms. Exciting new research shows th…
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