FTL1 Iron Protein Reversed Memory Loss in Old Mice
TL;DR: A 2025 mouse study in Nature Aging linked higher hippocampal FTL1 to iron handling, reduced mitochondrial energy, weaker synapses, and memory loss, with FTL1 targeting partly reversing decline. Key Findings Targeting FTL1 improved old-mouse cognition: The rescue result — reducing neuronal FTL1 in aged hippocampi improved synaptic-related molecular changes and cognitive impairments. A reversal …
