TL;DR: A 2025 mouse study in Nature Aging linked higher hippocampal FTL1 to iron handling, reduced mitochondrial energy, weaker synapses, and memory loss, with FTL1 targeting partly reversing decline. Key Findings Targeting FTL1 improved old-mouse cognition: The rescue result — reducing neuronal FTL1 in aged hippocampi improved synaptic-related molecular changes and cognitive impairments. A reversal …
TL;DR: A 2026 study in Molecular Psychiatry used PET imaging to link ketamine response in treatment-resistant depression to AMPA receptor changes across specific brain regions. Key Findings AMPA receptor density drops with illness severity: In treatment-resistant depression patients, lower levels of AMPA receptors on brain cell surfaces correlated strongly with symptom severity, particularly in frontal, …
TL;DR: A 2026 study in Molecular Psychiatry found that nitric oxide damaged TSC2 and overactivated mTOR signaling in autism-related mouse models, with nNOS inhibition reversing molecular and behavioral effects. Key Findings TSC2 S-nitrosylation increases: In both Shank3 and Cntnap2 knockout mice, nitric oxide chemically modifies TSC2 through a process called S-nitrosylation, which occurs in inhibitory …
TL;DR: A 2025 study in Science found that inhibiting DUSP6 extended ketamine-like antidepressant effects in mice by prolonging ERK-linked synaptic plasticity. The problem? The magic doesn’t last. By week two, most patients need another dose, and repeat dosing raises concerns about addiction, dissociation, and the burden of endless clinic visits. Now researchers have found a …
TL;DR: A 2026 study in Nature found that human memory content and context were represented by separate neuron populations whose coordinated activity predicted recall accuracy. Yet you experience memory differently. You recognize your friend’s face across a thousand contexts. You apply a fact learned once in infinite new situations. You imagine scenarios you’ve never lived. …
