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TL;DR: A 2026 study in Glia used human single-nucleus RNA sequencing datasets and mouse validation to identify a shared neurodegeneration-linked microglial transcription program, highlighting SPP1 as a disease-associated microglia marker. Key Findings Five dis…
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TL;DR: A 2026 preprint in medRxiv reported that serum myelin oligodendrocyte glycoprotein (MOG) protein was higher in multiple sclerosis than controls and higher during clinical relapse than remission. Key Findings 20.5 pg/ml higher: Serum MOG protein was high…
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TL;DR: A 2026 population-based matched cohort study in British Journal of Psychiatry found that risperidone use was associated with increased stroke risk, adjusted hazard ratio 1.28, while absolute stroke incidence was especially high in people with prior stro…
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TL;DR: A 2026 medRxiv preprint linked higher blood inflammatory markers with diffusion MRI signs of altered white-matter microstructure in 457 dementia-free middle-aged and older adults, especially for a combined cytokine score and orientation dispersion index…
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TL;DR: A 2026 Neurological Sciences study followed 216 early Parkinson’s patients for 2 years after levodopa started and found that several non-motor symptom differences between men and women persisted or emerged despite adjustment for baseline scores and levo…
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TL;DR: A 2026 study in Neurology found that higher autonomic symptom burden in moderate-advanced dementia with Lewy bodies was linked to worse cognitive fluctuations, higher neuropsychiatric burden, and lower caregiver quality of life over time. Key Findings A…
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TL;DR: A 2026 medRxiv preprint found that specific AD8 dementia-screening items, especially judgment, repetition, finances, tool use, and daily memory problems, tracked functional and psychosocial vulnerability in 144 Chinese-speaking older adults. Key Finding…
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TL;DR: A 2026 modeling study in Journal of Mathematical Biology found that delayed unfolded protein response (UPR), a cellular stress program that slows protein production, could make toxic prion protein either die out, persist, or oscillate as it spreads thro…
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TL;DR: A 2026 medRxiv preprint found psychomotor retardation, meaning slowed movement, speech, and thinking during depression, was linked to higher later Parkinson’s diagnosis risk in 6,327 London mental-health records. Key Findings Psychomotor retardation was…
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TL;DR: A 2026 medRxiv preprint used total-body tau PET in Alzheimer’s disease and found stronger brain-organ network synchrony, a pattern that tracked cognitive impairment through cortical tau burden and MRI markers of glymphatic dysfunction. Key Findings Smal…
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