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TL;DR: A 2026 study in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring found that each 10% higher energy share from ultra-processed foods was associated with lower attention scores and higher modifiable dementia-risk scores in 2,192 dementia…
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TL;DR: A 2026 study in PLOS Medicine found that severe infections stayed linked to later dementia in Finland even after researchers accounted for a broad set of noninfectious comorbid diseases. Key Findings 62,555 dementia cases: The analysis matched Finnish a…
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TL;DR: A 2026 systematic review and meta-analysis in Molecular Neurobiology found that plasma phosphorylated tau 217 (p-tau217), a blood marker of Alzheimer-linked tau pathology, identified biomarker-defined Alzheimer’s disease with pooled sensitivity of 85.4%…
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TL;DR: A 2026 medRxiv preprint tested SimulAD, an Alzheimer’s disease progression simulator, and reported that it reproduced mean amyloid-clearance results within 5% error across six major phase III anti-amyloid trials while also separating positive trials fro…
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TL;DR: A 2026 study in Nature Neuroscience from Baylor College of Medicine showed that boosting Sox9, a transcription factor that regulates aging astrocytes, improved astrocytes’ ability to clear amyloid plaques in Alzheimer’s mouse models and preserved cognit…
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Blood GFAP Started Mirroring the Brain Only After the BBB Leaked TL;DR: Blood biomarkers mostly failed to mirror the brain while the blood-brain barrier stayed intact; once the barrier leaked, glial fibrillary acidic protein (GFAP), an astrocyte injury protein…
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TL;DR: A CAR-style therapy aimed at astrocytes turned brain support cells into amyloid cleaners, preventing plaque development and cutting existing plaque burden by about half in mice. Key Findings Plaque-free prevention arm: Young mice treated before plaques…
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Vigorous Activity Linked to Lower Dementia Risk in UK Biobank TL;DR: In UK Biobank accelerometer data, the vigorous share of daily movement accounted for 32% of dementia’s population-attributable fraction versus just 8% for total activity volume — suggesting b…
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Body Roundness Index Flagged Depression Risk in Dementia TL;DR: Body roundness index, not BMI, flagged a dementia subgroup with more than threefold higher odds of depressive symptoms. Key Findings Highest BRI tripled odds: Among people with dementia, those in…
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How Focused Ultrasound Reprogrammed Microglia in Alzheimer’s Rats TL;DR: In TgF344-AD rats, repeated low-intensity focused ultrasound triggered a short-lived inflammatory response, then left behind a more durable microglial metabolic shift in early disease wit…
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