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TL;DR: A 2026 study in Neurology Open Access found that in 793 dementia-free adults, higher vitamin D levels around age 39 were associated with less tau readout on PET brain imaging about 16 years later, while amyloid beta did not show the same relationship. K…
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TL;DR: A 2026 study in Translational Psychiatry found that three different plasma p-tau217 assays separated Alzheimer’s dementia from controls and frontotemporal degeneration with excellent accuracy, shifting the test from whether the marker works to which pla…
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TL;DR: A 2026 Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring study found that orbitofrontal and frontoinsular visual rating scales on MRI helped distinguish possible from probable behavioral variant frontotemporal dementia. Key Findings bvF…
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TL;DR: A 2026 study in Nature Communications found that self-administered finger-prick blood tests for phosphorylated tau 217 (p-tau217), an Alzheimer’s tau marker, and glial fibrillary acidic protein (GFAP), an astrocyte-injury marker, correlated with cogniti…
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TL;DR: A 2026 study in Translational Neurodegeneration found that reducing NDST3, a microtubule deacetylase that affects lysosome acidity, restored lysosomal acidification and reduced amyloid-beta and tau pathology in Alzheimer’s cell and mouse models. Key Fin…
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TL;DR: A 2026 article-in-press study in Alzheimer’s Research & Therapy found that olfactory-region MRI radiomics, a method that turns brain scans into quantitative texture and shape features, linked blood pTau217, a tau-related Alzheimer’s disease biomarker, w…
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TL;DR: A 2025 study in Neurochemistry International from Kindai University showed that oral arginine, a naturally occurring amino acid, blocked the formation of toxic amyloid-beta aggregates in lab tests and reduced amyloid pathology in two well-established mo…
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TL;DR: A 2026 study in JAMA Network Open analyzed Medicare claims for adults 66+ from 2008 to 2021 and found that cognition-altering medications — antipsychotics, benzodiazepines, hypnotics, anticholinergics — were disproportionately initiated in emergency roo…
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TL;DR: A 2026 systematic review in The Cochrane Database of Systematic Reviews pooled 17 trials of anti-amyloid monoclonal antibodies (N=20,342 people with mild cognitive impairment or mild Alzheimer’s dementia) and concluded that any effect on memory decline…
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TL;DR: A 2026 medRxiv preprint found that plasma p-tau217 AI models still separated amyloid-positive from amyloid-negative people across ADNI and A4, but calibration drift made the same probabilities less dependable for clinical decisions. Key Findings Calibra…
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