TL;DR: A 2026 BJPsych Open study found clinically significant anxiety in about 18% of non-demented ALS patients for state anxiety and 14% for trait anxiety, with anxiety scores driven mainly by cognitive-affective depression symptoms rather than motor severity. Key Findings ALS cohort: The study compared 433 non-demented ALS patients with 313 healthy controls. State anxiety: …
TL;DR: A 2026 medRxiv preprint found that white matter hyperintensity (WMH) burden, the amount of MRI-visible white-matter injury, was greater and progressed faster in amyotrophic lateral sclerosis (ALS), with progression tied to worse motor and cognitive scores. Key Findings 369-person MRI sample: Researchers analyzed 204 ALS patients and 165 healthy controls from the Canadian ALS …
TL;DR: A 2026 medRxiv preprint reported that ventral capsule deep brain stimulation (DBS), an implanted brain-stimulation treatment, reduced severe treatment-resistant obsessive-compulsive disorder (OCD) symptoms by 22 Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) points on average in 10 participants. Key Findings 10 severe OCD patients: Researchers implanted bilateral ventral internal capsule DBS leads in participants with intractable obsessive-compulsive …
TL;DR: A 2026 medRxiv preprint found that serum hydrogen sulfide (H2S) levels, a blood measure tied to brain signaling and inflammation biology, were about 7.7-fold lower in drug-naive major depressive disorder patients than in matched controls. Key Findings 100-person comparison: Researchers enrolled 50 drug-naive major depressive disorder patients and 50 age- and sex-matched healthy controls …
TL;DR: A 2026 pilot study in Food & Function found that one month of extra virgin olive oil intake was associated with higher resting-state occipital functional connectivity than regular olive oil in 9 healthy young adults. Key Findings Occipital connectivity was the imaging endpoint: The 9-person neuroimaging substudy came from a larger randomized crossover trial …
TL;DR: A 2026 mouse preprint in bioRxiv found that psilocybin reduced firing in somatostatin (SST) interneurons, inhibitory cortical cells that gate dendritic input, while increasing parvalbumin (PV) interneuron firing in the medial frontal cortex. Key Findings SST firing decreased: Opto-tagged SST interneurons fell from 5.5 to 3.7 Hz after psilocybin, while saline did not produce …
TL;DR: A 2026 systematic review and exploratory network meta-analysis of 5 randomized trials in Neurological Sciences found dose-specific ON-medication motor improvements, measured while usual Parkinson’s drugs were active, for some GLP-1 receptor agonists, glucose-related metabolic hormone drugs, in Parkinson’s disease, but broader motor, non-motor, and quality-of-life evidence remained limited. Key Findings 5 randomized trials: The …
TL;DR: A 2026 systematic review and meta-analysis in Neuropsychopharmacology found that dopamine D2-like receptor activation suppressed glucose-stimulated insulin secretion (GSIS), insulin release after high glucose, in animal pancreatic cells, suggesting one peripheral route by which antipsychotic dopamine blockade can disturb glucose control beyond weight gain. Key Findings 39 eligible studies: Researchers screened 12,457 citations and …
TL;DR: A 2025 scoping review in European Psychiatry screened 292 randomized trials of adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) and reported that 49.7% did not assess general psychopathology and only 35% had the ADHD diagnosis allocated by a psychiatrist or psychologist. Key Findings Half of the trials skipped a general psychopathology check: 49.7% of the …
TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the prefrontal cortex, and showed no rewarding or reinforcing properties at the tested doses. Key Findings Despair behavior fell after …
