Psychology

Mental Health Apps Split Depression, Anxiety, and Workplace Well-Being Effects

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Mental Health Apps Split Depression, Anxiety, and Workplace Well-Being Effects

TL;DR: A 2026 randomized trial in JMIR Mental Health found that a 4-week executive-function training app reduced depression and anxiety symptoms at 12-week follow-up, while a self-guided CBT app mainly improved workplace well-being. Key Findings Workplace app trial: Participants with mild-to-moderate depression and anxiety symptoms were assigned to waitlist control, NeuroNation executive-function training, or Moodfit …

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Laypeople Named More Alcohol Than Cannabis Intoxication Cues

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Laypeople Named More Alcohol Than Cannabis Intoxication Cues

TL;DR: A 2026 study in Drug and Alcohol Review found that laypeople reported more and better-developed cues for alcohol intoxication than cannabis intoxication, even though most coded cues for both substances were accurate. Key Findings Intoxication-cue sample: The survey sample was 77.7% female, with an average age of 20.5 years, and came from undergraduate psychology …

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Five Adolescent Emotion-Regulation Profiles Tracked Mental Health

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Five Adolescent Emotion-Regulation Profiles Tracked Mental Health

TL;DR: A 2026 study in Research on Child and Adolescent Psychopathology followed 951 New Zealand adolescents and found that 5 emotion-regulation profiles tracked different patterns of anxiety, depression, optimism, resilience, and wellbeing over 5 months. Key Findings 951 adolescents were studied: The sample completed the Process of Emotion Regulation Measure (PERM), a tool that separates …

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PF-04995274 5-HT4 Agonist Changed Depression Signals Without SSRI-Like Bias Shift

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PF-04995274 5-HT4 Agonist Changed Depression Signals Without SSRI-Like Bias Shift

TL;DR: A 2026 randomized study in The British Journal of Psychiatry found that the experimental 5-HT4 receptor agonist PF-04995274 did not mimic citalopram’s early emotional-bias effects in unmedicated depression, but it was linked with lower depression ratings and increased medial-frontal brain activation after about 1 week. Key Findings 90 randomized adults: The RESTAND study assigned …

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5-10 mg THC Did Not Broadly Reduce Stress-Memory Responses

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5-10 mg THC Did Not Broadly Reduce Stress-Memory Responses

TL;DR: A 2026 study in Psychopharmacology found that low oral THC doses did not meaningfully reduce most subjective or physiological responses when healthy adults retrieved memories of a prior social stress task. Key Findings Low-dose THC groups: Participants aged 18-35 were assigned to placebo, 5 mg THC, or 10 mg THC groups, with 12 people …

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Psilocybin AUD Trial Found Exploratory TLE4 and RASGRP4 Methylation Signals

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Psilocybin AUD Trial Found Exploratory TLE4 and RASGRP4 Methylation Signals

TL;DR: A 2026 exploratory study in Translational Psychiatry found blood DNA methylation changes after 25 mg psilocybin in detoxified alcohol use disorder patients, including findings near TLE4 and RASGRP4, but the small trial did not establish a definitive AUD biomarker. Key Findings 37 AUD patients: The methylation analysis used a randomized, double-blind psilocybin trial completed …

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Chicory and Green Tea Sleep Supplement Did Not Beat Placebo in Insomnia Pilot

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Chicory and Green Tea Sleep Supplement Did Not Beat Placebo in Insomnia Pilot

TL;DR: A 2026 pilot trial in PLOS One found that a 7-day chicory-and-green-tea herbal supplement did not improve sleep, quality of life, or objective sleep architecture more than placebo in adults with insomnia. Key Findings Small crossover pilot: The crossover pilot enrolled 10 adults aged 50 years or older with insomnia; 9 were women and …

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Amygdala-ACC Connectivity Was Reduced in Anxiety Disorders Meta-Analysis

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Amygdala-ACC Connectivity Was Reduced in Anxiety Disorders Meta-Analysis

TL;DR: A 2026 meta-analysis in Psychological Medicine found that reduced resting-state connectivity between the amygdala and anterior cingulate cortex was the most robust brain-network difference in anxiety disorders. Key Findings 15 datasets: The meta-analysis pooled 14 studies with 15 independent datasets of amygdala-based resting-state functional MRI. 783 total participants: Included samples covered 378 people with …

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Psychosis in Lupus Linked to Immune Disease Activity in Review

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Psychosis in Lupus Linked to Immune Disease Activity in Review

TL;DR: A 2026 systematic review and meta-analysis in Lupus found that psychosis affected about 4.5% of adults with systemic lupus erythematosus (SLE), was more common in neuropsychiatric SLE, and tracked most strongly with active immune disease markers rather than serving as a stand-alone psychiatric label. Key Findings Sixty-five studies were included: The review covered 31,495 …

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Head Impact MEG Changes Mapped to Neurochemical Brain Systems

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Head Impact MEG Changes Mapped to Neurochemical Brain Systems

TL;DR: A 2026 preprint in medRxiv found that head-impact-related magnetoencephalography (MEG) changes in high-school football players were strongest in cortical regions matching specific neurotransmitter and gene-expression maps, especially norepinephrine, nicotinic acetylcholine, APOE, and BDNF-related patterns. Key Findings MEG tracked pre-to-post-season brain signaling across 278 timepoints from 91 male high-school football players. Concussion-related cortical slowing aligned …

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