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TL;DR: A 2026 randomized trial in Nature and Science of Sleep found that Sancai acupoint acupuncture reduced primary-insomnia severity more than sham acupuncture, with parallel improvements in sleep testing and peripheral 5-HT and BDNF biomarkers. Key Findings…
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TL;DR: A 2026 preprint in medRxiv linked recurrent major depression to direction-specific effective-connectivity changes, with strongest patterns in cerebellar-cortical, sensorimotor, cognitive, neurotransmitter, and oligodendrocyte precursor cell maps. Key Fi…
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TL;DR: A 2026 study in BJPsych Open found that closely monitored antidepressant care improved quality of life and reduced societal costs in both PReDicT and usual-care groups, while the PReDicT algorithm added uncertain, country-dependent economic value. Key F…
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TL;DR: A 2026 study in iScience found that 1 hour of small-space confinement suppressed male courtship in Drosophila, and dopamine signaling into the mushroom body was needed to keep that suppression going after the stress ended. Key Findings 1-hour stress mod…
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TL;DR: A 2026 systematic review and meta-analysis in Journal of Sleep Research found that agomelatine modestly improved subjective sleep quality versus placebo, but objective total sleep time did not significantly increase and somnolence reports were more freq…
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TL;DR: A 2026 review in Neuropsychiatric Disease and Treatment argues that miR-425-3p is a candidate depression biomarker because it connects stress biology, MAPK/Wnt signaling, inflammation, and antidepressant response evidence. Key Findings 280 million MDD b…
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TL;DR: A 2026 study in Interactive Journal of Medical Research used structured hospital records plus natural language processing of clinical notes to profile major depressive disorder in Belgium, finding that 46% of 1,147 adults met a real-world treatment-resi…
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TL;DR: A 2026 preprint posted on medRxiv found that iSupport-Malaysia, a culturally adapted multimedia dementia-caregiver platform, scored above the usual usability benchmark and was viewed as culturally appropriate by caregivers and healthcare professionals.…
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TL;DR: A 2026 study in iScience found that migraine patients with patent foramen ovale had altered plasma metabolic profiles, with lower indoleacrylic acid and an IA-plus-hs-CRP marker pair showing exploratory discrimination in a validation cohort. Key Finding…
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TL;DR: A 2026 systematic review in Preventive Medicine Reports found limited but suggestive randomized-trial evidence that smoking-cessation medications can help Indigenous adults quit, especially when paired with supportive or culturally tailored care. Key Fi…
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