EXPLORE THE SCIENCE
TL;DR: A 2026 review in Translational Neuroscience summarizes why PINK1 and parkin, two genes linked to early-onset parkinsonism, keep pointing researchers back to mitophagy and autophagy as Parkinson disease mechanisms. Key Findings 18 PARK loci noted: The re…
Read article
TL;DR: A 2026 study in Biochemistry and Biophysics Reports found that cannabinoid receptor 1 (CB1R) undergoes autophagy-linked degradation in mouse cortical neurons, but p62 deficiency did not make CB1R the main driver of obesity and low activity in p62 knocko…
Read article
TL;DR: A 2026 study in Translational Neurodegeneration found that reducing NDST3, a microtubule deacetylase that affects lysosome acidity, restored lysosomal acidification and reduced amyloid-beta and tau pathology in Alzheimer’s cell and mouse models. Key Fin…
Read article
Chlorpyrifos Linked to 2.5x Higher Parkinson’s Risk TL;DR: A pesticide sprayed on US crops decades ago more than doubles your risk of Parkinson’s disease, and new research shows exactly how it damages dopamine neurons. You probably never heard of chlorpyrifos,…
Read article
Antidepressants could potentially be repurposed as anticancer agents based on emerging evidence showing they can modulate autophagy—a process cancer cells rely on for growth and survival. Key Facts: Many antidepressants like SSRIs and TCAs have demonstrated an…
Read article