TL;DR: A 2026 study in Translational Psychiatry found that three different plasma p-tau217 assays separated Alzheimer’s dementia from controls and frontotemporal degeneration with excellent accuracy, shifting the test from whether the marker works to which platform clinics can deploy. Key Findings Three p-tau217 assays all performed strongly: The cohort included 39 cognitively unimpaired controls, 28 …
TL;DR: A 2025 systematic review in Translational Psychiatry found that substance use disorder was associated with recurring resting-state functional MRI (rs-fMRI), a scan of spontaneous brain-network communication, abnormalities in reward and self-control circuits across 53 studies. Key Findings 53-study meta-analysis: Researchers pooled whole-brain rs-fMRI studies covering 1,700 people with substance use disorder and 1,792 healthy …
Ketamine Restored Reward Bias Across Species TL;DR: Ketamine restored reward-learning bias in both treatment-resistant depression and chronically stressed rats while leaving basic discrimination unchanged. Key Findings Reward bias increased: Ketamine significantly increased response bias toward the more frequently rewarded stimulus in both species. Healthy-control levels returned: The reward-bias effect reached levels comparable with healthy controls …
