TL;DR: A 2026 study in Biochemistry and Biophysics Reports found that cannabinoid receptor 1 (CB1R) undergoes autophagy-linked degradation in mouse cortical neurons, but p62 deficiency did not make CB1R the main driver of obesity and low activity in p62 knockout mice. Key Findings CB1R accumulated up to 10-fold: Blocking autophagic flux with Bafilomycin A1 in …
TL;DR: A 2026 study in Nature Communications found that different brain-connectivity measures predicted different parts of associative learning: functional connectivity predicted acquisition, structural connectivity predicted extinction learning, and effective connectivity was most informative for renewal. Key Findings 509 resting-state fMRI scans: Researchers analyzed resting-state functional MRI data from 509 participants across six learning studies. 463 …
TL;DR: A 2026 Research Square preprint linked DNA methylation (DNAm), an epigenetic mark measured in cord blood at birth, with default mode network-limbic brain development and age-13 anxiety symptoms in boys. Key Findings Birth-to-teen pathway tested: Researchers analyzed 97 children from the GUSTO birth cohort who had cord-blood DNAm, repeated resting-state functional MRI (fMRI) scans, …
TL;DR: A 2026 preprint in medRxiv found that 26 autistic children and 25 typically developing peers performed similarly on iPad-based navigation tasks, but the autistic group rated its own sense of direction lower. Key Findings Objective navigation performance did not differ between autistic and typically developing children across path integration, egocentric pointing, mapping, or perspective …
TL;DR: A 2026 case study in Neurological Sciences described 2 Tourette syndrome patients who developed oculogyric crisis, a sustained upward eye-rolling dystonia, after aripiprazole was increased to 20-30 mg/day, with both cases resolving after dose reduction. Key Findings 2 Tourette cases: The report described 2 female patients, ages 16 and 22, treated with aripiprazole for …
TL;DR: A 2026 medRxiv preprint reported that Hwa-free, a 4-week acceptance and commitment therapy app for Hwa-byung, was used on an average of 19.9 of 28 days and was followed by lower Hwa-byung symptoms, depression scores, and state anger in a small single-arm pilot trial. Key Findings 28-person analysis: Researchers enrolled 30 adults with Hwa-byung, …
TL;DR: A 2026 cross-sectional study in Metabolic Brain Disease linked adult attention-deficit/hyperactivity disorder (ADHD) with lower serum SIRT-1, Nrf-2, and HO-1, three redox-regulation markers tied to antioxidant defense. Key Findings 120 adults studied: The analysis compared 60 adults with ADHD against 60 age- and sex-matched healthy controls. SIRT-1 was lower: Mean serum SIRT-1 was 9.36 …
TL;DR: A 2026 medRxiv preprint found that specific AD8 dementia-screening items, especially judgment, repetition, finances, tool use, and daily memory problems, tracked functional and psychosocial vulnerability in 144 Chinese-speaking older adults. Key Findings Small community sample: The cross-sectional study included 144 Chinese-speaking adults with a mean age of 73.1 years. Three AD8 domains: Exploratory factor …
TL;DR: A 2026 case-series study in Indian Journal of Psychological Medicine reported rapid pain and symptom improvement after accelerated transcranial direct current stimulation in 4 of 5 patients with treatment-resistant bodily distress disorder. Key Findings 5 BDD cases: The series included 5 patients with bodily distress disorder, a condition involving persistent distressing physical symptoms and …
TL;DR: A 2026 case study in Psychiatry and Clinical Neurosciences Reports described a 36-year-old man with treatment-resistant schizophrenia and focal epilepsy whose psychosis improved after slow clozapine titration, without worsening seizure frequency or severity during monitored hospitalization. Key Findings Clozapine reached 250 mg/day: Treatment started at 6.25 mg and was titrated slowly over more than …
