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TL;DR: A 2025 human proteomics study in Molecular Metabolism found that about 10 days of medically supervised water-only fasting caused weight loss and lower circulating amyloid beta proteins, but also increased inflammatory and platelet-activation markers. Ke…
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TL;DR: A 2026 study in BJPsych Open found that closely monitored antidepressant care improved quality of life and reduced societal costs in both PReDicT and usual-care groups, while the PReDicT algorithm added uncertain, country-dependent economic value. Key F…
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TL;DR: A 2026 study in Radiology Case Reports described a 14-year-old boy whose seizure workup found a rare congenital left parahippocampal herniation on MRI, with imaging features that favored a benign developmental variant rather than tumor or acute brain he…
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TL;DR: A 2026 methods paper in Nature Methods describes Neuropixels Opto probes that combine high-density neural recording with spatially addressable blue and red optogenetic stimulation in 1 mouse-brain device. Key Findings 960 recording sites: Each prototype…
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TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatme…
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TL;DR: A 2026 study in iScience found that 1 hour of small-space confinement suppressed male courtship in Drosophila, and dopamine signaling into the mushroom body was needed to keep that suppression going after the stress ended. Key Findings 1-hour stress mod…
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TL;DR: A 2026 systematic review and meta-analysis in Journal of Sleep Research found that agomelatine modestly improved subjective sleep quality versus placebo, but objective total sleep time did not significantly increase and somnolence reports were more freq…
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TL;DR: A 2026 preprint in medRxiv surveyed people with multiple system atrophy and found that neurogenic orthostatic hypotension was often underdiagnosed, rarely fully controlled, and strongly tied to daily function and caregiver burden. Key Findings 259 MSA r…
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TL;DR: A 2026 review in Neuropsychiatric Disease and Treatment argues that miR-425-3p is a candidate depression biomarker because it connects stress biology, MAPK/Wnt signaling, inflammation, and antidepressant response evidence. Key Findings 280 million MDD b…
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TL;DR: A 2026 study in Interactive Journal of Medical Research used structured hospital records plus natural language processing of clinical notes to profile major depressive disorder in Belgium, finding that 46% of 1,147 adults met a real-world treatment-resi…
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