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TL;DR: A 2026 medRxiv preprint found that specific AD8 dementia-screening items, especially judgment, repetition, finances, tool use, and daily memory problems, tracked functional and psychosocial vulnerability in 144 Chinese-speaking older adults. Key Finding…
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TL;DR: A 2026 randomized clinical trial in the Journal of Sport and Health Science assigned 130 midlife adults to 150 minutes/week aerobic exercise or no-exercise control for 1 year and found sustained lower long-term cortisol in the exercise group. Key Findin…
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TL;DR: A 2025 study in The Journal of Prevention of Alzheimer’s Disease found that stress internalization, not acculturation or activity engagement, predicted memory decline across three waves in 1,528 older Chinese Americans. Key Findings Stress internalizati…
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TL;DR: A 2026 MIDUS mediation study in Brain, Behavior, & Immunity – Health found that social asymmetry was associated with greater chronic disease burden, while chronic disease burden mediated links between social asymmetry and episodic memory and executive f…
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TL;DR: A 2026 medRxiv preprint used quantitative multi-parametric MRI mapping in 245 BeLOVE participants and found that white matter hyperintensities had lower MTsat and R1 plus higher proton density, with nearby normal-appearing white matter also showing micr…
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TL;DR: A 2026 mouse preprint in bioRxiv reported that small-molecule IGF1R inhibitors, drugs that block insulin-like growth factor 1 receptor signaling, protected several healthspan measures in aging mice, but the tested compounds also carried major safety and…
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TL;DR: A 2026 Nature Communications study found that mouse hippocampal CA3 connectivity shifts from dense-random early wiring to sparse-structured adult wiring, with weaker single synapses that make memory-network output depend on coordinated input rather than…
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TL;DR: A 2026 preprint longitudinal cohort analysis in medRxiv found that later-born cohorts showed higher memory levels entering old age and slower rates of memory decline, while the projected 20-year cohort advantage at age 80 was large enough in the model t…
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TL;DR: A 2026 longitudinal analysis in the Journal of Affective Disorders tracked 635 older adults with new-onset loneliness and found that cognitive decline matched controls before loneliness began, then accelerated after onset, especially when loneliness per…
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TL;DR: A 2026 preprint on medRxiv using the Harvard Biomarkers Study found that 43% of Parkinson’s disease patients had depression, anxiety, sleep apnea, or restless legs syndrome, compared with 21% of controls. Key Findings 1,224-person cohort: Researchers an…
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