Flakka, the latest dangerous designer drug, has rapidly spread across the United States and beyond. This synthetic cathinone has powerful stimulant effects leading to delirium, aggression, dangerous health issues, and even death. What is Flakka and Why Is It So Troubling? Flakka, commonly referred to as gravel or bath salts, is the street name for …
The presence of pharmaceuticals in the environment has become a growing concern, with increasing evidence that these compounds can impact wildlife at low, environmentally relevant levels. One drug in particular – the popular antidepressant fluoxetine (Prozac) – deserves special attention due to its potential effects on brain function and behavior. Key Facts: Fluoxetine is commonly …
Ibogaine, an alkaloid derived from the Tabernanthe iboga shrub found in Africa, has received attention as a potential treatment for addiction, particularly opioid use disorder. While small studies have hinted at effectiveness, a new clinical study shows ibogaine comes with concerning safety risks that may limit its therapeutic potential. Key facts: Ibogaine resulted in significant …
Ayahuasca is a traditional psychedelic brew from the Amazon that has been used for centuries in shamanic healing rituals. Research is now exploring its potential therapeutic benefits for mental health and addiction. Key Facts: Ayahuasca contains DMT, a hallucinogenic compound, along with MAOIs from the vine Banisteriopsis caapi. The MAOIs allow the DMT to be …
Cocaine use can lead to significant structural changes and accelerated aging of the brain, according to a new study. Key findings include: Cocaine users showed widespread gray matter loss in areas involved in emotions, language, cognition and decision-making. Cocaine users had “older” looking brains, with brain-predicted age 2.5 years higher than their real age. Brain …
Classical psychedelics like LSD and psilocybin have recently re-entered mainstream discussions surrounding mental health. Small clinical trials have shown promising results for their therapeutic potential in treating conditions like depression, anxiety and addiction. However, beyond their clinical utility, many questions remain regarding the impact of these substances on psychological aspects like personality and belief systems. …
Brain serotonin is crucially involved in regulating mood, social behavior, and physical health. While medications that alter serotonin levels have revolutionized psychiatry, non-drug approaches may provide safer, sustainable ways to optimize serotonin and promote wellbeing. Key Facts: Brain serotonin influences mood, sociability, and health in animals and humans. Higher serotonin is linked to positive mood, …
Researchers have uncovered new evidence that a traditional Chinese herbal medicine may be a safe, effective option for treating depression. The formula, known as Chaihu-jia-Longgu-Muli-tang (CLM) also phrased “Chai Hu Jia Long Gu Mu Li Tang,” outperformed standard antidepressants in clinical trials and appears to work via multiple mechanisms in the brain. Key findings: In …
Suicide is a major global public health problem, accounting for over 800,000 deaths worldwide each year. Lithium, a mood stabilizing medication, has been proposed as a novel population-level suicide prevention strategy through supplementation of trace doses into the public drinking water supply. This controversial idea has sparked much debate around its ethics, risks, benefits and …
Borderline personality disorder (BPD) is a common and debilitating mental health condition, yet medication options remain limited according to a new systematic review published in CNS Drugs. The study found minimal evidence supporting the benefits of medication for BPD beyond some improvement in individual symptoms. No drugs have been approved for BPD and there is …
