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TL;DR: A 2026 randomized trial in Scientific Reports found that adding esketamine to sufentanil patient-controlled analgesia lowered short-term postoperative depression and anxiety scores in elderly colorectal cancer surgery patients, without improving pain sc…
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TL;DR: A 2026 paper in Current Therapeutic Research described an acute PGAD-like genital arousal episode after self-initiated duloxetine withdrawal, with symptoms resolving within 5 hours after emergency admission and no recurrence over 36 months. Key Findings…
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TL;DR: A 2026 mouse study in iScience found that blocking Itch, an E3 ubiquitin ligase involved in protein tagging, improved several memory-test readouts in an Alzheimer’s disease mouse model and reduced neuronal apoptosis, including when researchers used the…
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TL;DR: A 2026 study in Psychopharmacology found that healthy adults who used cannabis frequently had higher circulating THC markers after at least 12 hours of verified abstinence, but their cold-pressor pain threshold, pain tolerance, and pain ratings did not…
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TL;DR: A 2026 BMC Psychiatry study found that antipsychotic dose was not associated with Montreal Cognitive Assessment (MoCA), a brief cognitive screening test, in clinically stable schizophrenia patients under 40, while higher symptom scores and longer illnes…
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TL;DR: A 2026 preprint in medRxiv from the CORE-VNS study reported that vagus nerve stimulation (VNS), a neuromodulation therapy for drug-resistant epilepsy, produced similar 36-month seizure reductions in people with and without prior intracranial epilepsy su…
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TL;DR: A 2026 study in Neuron from Weill Cornell used mouse melanoma models to find that sympathetic nerves growing into tumors release norepinephrine, which activates alpha adrenergic receptors on tumor-associated macrophages and reduces their pro-tumor numbe…
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TL;DR: A 2026 study in BJGP Open found no clear cohort-level increase in major bleeding outcomes when selective serotonin reuptake inhibitors (SSRIs) were used with direct oral anticoagulants (DOACs), but the self-controlled analysis still pointed to extra cau…
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TL;DR: A 2026 study in PNAS from Oregon Health & Science University and Anhui University used optogenetics in mice to map a specific serotonin-producing brain circuit that runs straight to the auditory system, showed that activating this circuit produced tinni…
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TL;DR: A 2026 population-based matched cohort study in British Journal of Psychiatry found that risperidone use was associated with increased stroke risk, adjusted hazard ratio 1.28, while absolute stroke incidence was especially high in people with prior stro…
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