TL;DR: A 2026 systematic review and meta-analysis in Journal of Sleep Research found that agomelatine modestly improved subjective sleep quality versus placebo, but objective total sleep time did not significantly increase and somnolence reports were more frequent. Key Findings 25 RCTs: The review included 25 double-blind randomized controlled trials with 6,812 randomized participants. Subjective sleep …
TL;DR: A 2026 preprint in medRxiv surveyed people with multiple system atrophy and found that neurogenic orthostatic hypotension was often underdiagnosed, rarely fully controlled, and strongly tied to daily function and caregiver burden. Key Findings 259 MSA respondents: The survey analyzed 259 people with self-reported multiple system atrophy, with mean age 64.38 years and 44% …
TL;DR: A 2026 review in Neuropsychiatric Disease and Treatment argues that miR-425-3p is a candidate depression biomarker because it connects stress biology, MAPK/Wnt signaling, inflammation, and antidepressant response evidence. Key Findings 280 million MDD burden: The review opens from the scale of major depressive disorder, which affects more than 280 million people worldwide. About 20-fold …
TL;DR: A 2026 study in Interactive Journal of Medical Research used structured hospital records plus natural language processing of clinical notes to profile major depressive disorder in Belgium, finding that 46% of 1,147 adults met a real-world treatment-resistant depression definition. Key Findings Belgian EHR cohort: The retrospective study drew from 1,147 adults with major depressive …
TL;DR: A 2026 study in Nature Communications used cryo-electron microscopy and patch-clamp recordings to show how partially occupied GluK2/GluK5 kainate receptors can activate without entering the fast desensitized state that normally shuts glutamate receptors down. Key Findings Fast glutamate shutdown: Glutamate triggered receptor activation in less than 1 ms, followed by complete desensitization in about …
TL;DR: A 2026 study in iScience found that migraine patients with patent foramen ovale had altered plasma metabolic profiles, with lower indoleacrylic acid and an IA-plus-hs-CRP marker pair showing exploratory discrimination in a validation cohort. Key Findings 30 discovery patients: Untargeted metabolomics compared 30 migraine patients with patent foramen ovale against 17 matched controls. 4,858 …
TL;DR: A 2026 systematic review in Preventive Medicine Reports found limited but suggestive randomized-trial evidence that smoking-cessation medications can help Indigenous adults quit, especially when paired with supportive or culturally tailored care. Key Findings 5 RCTs: The review found only 5 randomized controlled trials, totaling 1,633 participants, in American Indian, Alaska Native, and Maori adult …
TL;DR: A 2026 narrative review in Journal of Central Nervous System Disease found that glucagon-like peptide-1 receptor agonists have promising stroke-prevention and animal-model evidence, but human data do not yet support routine use as an acute ischemic stroke neuroprotective treatment. Key Findings Search through January 2026: The review covered preclinical stroke models, observational studies, randomized …
TL;DR: A 2026 Nature study found that satellite glial cells can transfer mitochondria to sensory neurons, and blocking that transfer in mice promoted nerve degeneration and neuropathic pain. Key Findings 83.3% transfer: In mouse co-cultures, 83.3% of dorsal root ganglion neurons received mitochondria from satellite glial cells. 31.3% TNT-positive: Visible tunnelling nanotubes were seen in …
TL;DR: A 2026 review in Advances in Clinical and Experimental Medicine argues that autoimmune mechanisms may explain a subset of drug-resistant focal epilepsy, especially when seizures persist despite standard antiseizure drugs and immune markers are present. Key Findings Drug resistance definition: Drug-resistant epilepsy was defined as persistent seizures despite at least two appropriately selected, tolerated, …
