EXPLORE THE SCIENCE
TL;DR: A 2026 study in Cell & Bioscience found that poly-GR, a toxic repeat protein linked to C9orf72-ALS, pushed motor neuron-like cells toward ferroptosis by raising lipid peroxidation and ferrous iron while weakening the Nrf2/Slc7a11 antioxidant pathway. Ke…
Read article
TL;DR: A 2026 open-label feasibility trial in IBRO Neuroscience Reports tested an AI-guided variable levodopa schedule in 5 people with Parkinson’s disease and found 4 patients improved on UPDRS, but the study was far too small and uncontrolled to prove effica…
Read article
TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatme…
Read article
TL;DR: A 2026 preprint in medRxiv surveyed people with multiple system atrophy and found that neurogenic orthostatic hypotension was often underdiagnosed, rarely fully controlled, and strongly tied to daily function and caregiver burden. Key Findings 259 MSA r…
Read article
TL;DR: A 2026 preprint posted on medRxiv found that iSupport-Malaysia, a culturally adapted multimedia dementia-caregiver platform, scored above the usual usability benchmark and was viewed as culturally appropriate by caregivers and healthcare professionals.…
Read article
TL;DR: A 2025 mouse study in eNeuro reported that inhaled cannabidiol reduced IDO and cGAS pathway activity and lowered pro-inflammatory cytokines in male 5XFAD Alzheimer’s model mice. Key Findings 5XFAD model: The study used male 5XFAD transgenic mice, a comm…
Read article
TL;DR: A 2026 Nature study found that satellite glial cells can transfer mitochondria to sensory neurons, and blocking that transfer in mice promoted nerve degeneration and neuropathic pain. Key Findings 83.3% transfer: In mouse co-cultures, 83.3% of dorsal ro…
Read article
TL;DR: A 2026 preprint in medRxiv used amyloid positron-emission tomography, tau molecular imaging, and structural MRI to build individualized Alzheimer’s disease biomarker axes from ADNI and validate them in OASIS. Key Findings 12,430 ADNI images: The pipelin…
Read article
TL;DR: A 2026 study in Nature Communications used deep learning, yeast screening, and human brain organoids to identify talarozole and sertaconazole as preclinical candidates that rescued several SURF1-related Leigh syndrome cell and organoid phenotypes. Key F…
Read article
TL;DR: A 2026 systematic review in The Cerebellum found that deep brain stimulation (DBS) produced modest symptom improvement in selected cerebellar ataxia patients, with dentate nucleus stimulation most common in humans and interposed nucleus stimulation emer…
Read article