Fecal microbiota transplantation (FMT) shows potential as an effective new treatment for major depressive disorder (MDD). Key facts: FMT aims to restore a healthy gut microbiome which is thought to impact mood and mental health. Studies show links between gut microbiome abnormalities and depression. FMT has successfully treated depression symptoms in animal models. A few …
A new case-control study reveals an association between obesity, depression, and decreased levels of the protein neuregulin-1 (NRG-1). The research suggests NRG-1 may serve as a biomarker linking depression and obesity. Key facts: Depressive symptoms were more common in obese individuals compared to normal weight controls. After bariatric surgery, most obese patients saw an improvement …
Suicide is a leading cause of death globally, and people who use drugs are at heightened risk. Key facts: People who use opioids have 7-22 times the risk of suicide compared to the general population. Men who use drugs die by suicide more often, but women who use drugs have a higher proportional increase in …
Major depressive disorder (MDD) is one of the most prevalent mental health conditions worldwide, yet its complex neurobiological underpinnings remain poorly understood. Emerging research implicates disturbances in neuronal apoptosis and neuroplasticity in the development of depression. A new study led by researchers in Poland sheds light on the involvement of caspase-3, a key mediator of …
A new study suggests higher levels of remnant cholesterol may increase the risk of depression. Remnant cholesterol is a type of lipoprotein that contains triglycerides and cholesterol and has been linked to atherosclerosis and cardiovascular disease. This large study found remnant cholesterol levels were significantly higher in people with depression compared to those without. Key …
Major depressive disorder (MDD) is a highly prevalent and debilitating condition. Novel treatment approaches are needed, especially for individuals with treatment-resistant depression. This study investigated the effects of adjunctive minocycline on immune-inflammatory biomarkers and clinical outcomes in MDD. Key Highlights: Minocycline is a broad-spectrum antibiotic with anti-inflammatory, immunomodulatory and neuroprotective properties. It shows promise as …
Suicide is a devastating public health problem, claiming hundreds of thousands of lives worldwide each year. Understanding the underlying biological and psychological factors that increase suicide risk is key for developing effective prevention and intervention approaches. A recent article comprehensively reviews research on biological markers of suicidal thoughts and behaviors, providing important insights and guidance …
Depression affects over 120 million people worldwide, carrying a heavy burden of disability, mortality, and cost. While medications like SSRIs have provided relief for many, most patients fail to achieve full remission. After 30 years with few advances in pharmaceutical options, it may be time to rethink our approach to treating depression. Exciting new research …
Brain serotonin is crucially involved in regulating mood, social behavior, and physical health. While medications that alter serotonin levels have revolutionized psychiatry, non-drug approaches may provide safer, sustainable ways to optimize serotonin and promote wellbeing. Key Facts: Brain serotonin influences mood, sociability, and health in animals and humans. Higher serotonin is linked to positive mood, …
Researchers have uncovered new evidence that a traditional Chinese herbal medicine may be a safe, effective option for treating depression. The formula, known as Chaihu-jia-Longgu-Muli-tang (CLM) also phrased “Chai Hu Jia Long Gu Mu Li Tang,” outperformed standard antidepressants in clinical trials and appears to work via multiple mechanisms in the brain. Key findings: In …
