Stroke Thrombectomy Technique Preference Did Not Predict First-Pass Reperfusion

Stroke Thrombectomy Technique Preference Did Not Predict First-Pass Reperfusion

TL;DR: A 2026 medRxiv preprint found that stroke thrombectomy operators often had a preferred device technique, but that preference did not reliably match the technique with the highest first-pass reperfusion rate. Key Findings Stroke thrombectomy cohort: The single-center analysis included 1,405 acute ischemic stroke patients treated with mechanical thrombectomy from 2019 through 2024. 75% had …

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Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

TL;DR: Portable electroencephalography (EEG) recordings tracked perinatal anxiety most consistently in a preliminary medRxiv preprint, with delta power carrying the clearest longitudinal marker and alpha power appearing in visit-specific anxiety analyses. Key Findings First-trimester marker: Relative delta power before 16 gestational weeks was associated with third-trimester PHQ-9 depression and GAD-7 anxiety scores. Delta-anxiety link: Across …

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Syringe Service Buprenorphine Improved Access but Needed Withdrawal Support

Syringe Service Buprenorphine Improved Access but Needed Withdrawal Support

TL;DR: A 2026 qualitative study in the Journal of Substance Use and Addiction Treatment found that syringe service programs helped people receive buprenorphine quickly, but participants said precipitated withdrawal and limited at-home initiation guidance made treatment harder to start and continue. Key Findings 12 exit interviews: Researchers interviewed people after a randomized trial of buprenorphine …

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Psilocybin Therapy for Anorexia Nervosa Improved EDE Symptoms in Pilot Study

Psilocybin Therapy for Anorexia Nervosa Improved EDE Symptoms in Pilot Study

TL;DR: A 2026 pilot study in The British Journal of Psychiatry tested psilocybin-assisted therapy in 21 adult females with anorexia nervosa and found lower Eating Disorder Examination (EDE) symptom scores through 6 months, with large individual variation and no placebo-controlled comparison. Key Findings Single-arm pilot study: Researchers enrolled 21 adult females with anorexia nervosa and …

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Cerebellar Hypermetabolism Impaired Fronto-Cerebellar Connectivity in Alcohol Use Disorder

Cerebellar Hypermetabolism Impaired Fronto-Cerebellar Connectivity in Alcohol Use Disorder

TL;DR: A 2026 study in Translational Psychiatry combined positron emission tomography (PET) and functional MRI (fMRI) in alcohol use disorder and linked cerebellar hypermetabolism to disrupted fronto-cerebellar connectivity and poorer inhibition performance. Key Findings AUD-control sample: Researchers compared 27 people with severe alcohol use disorder (AUD) and 25 healthy controls. Multimodal imaging used: The study …

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Metformin and Semaglutide Metabolic Clinic Reduced Weight in Severe Mental Illness

Metformin and Semaglutide Metabolic Clinic Reduced Weight in Severe Mental Illness

TL;DR: A 2026 retrospective chart review in Acta Psychiatrica Scandinavica found that a psychiatrist-led metabolic clinic helped 132 of 378 patients with severe mental illness lose at least 5% of baseline body weight over 12 months. Key Findings Clinic outcomes were tracked: Researchers analyzed 378 people treated at the Centre for Addiction and Mental Health …

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Oxytocin Plus Mindfulness Group Therapy Reduced Schizophrenia Negative Symptoms

Oxytocin Plus Mindfulness Group Therapy Reduced Schizophrenia Negative Symptoms

TL;DR: A 2026 preprint on medRxiv found that adding 24 IU intranasal oxytocin before 4 mindfulness-based group therapy sessions was linked to larger clinician-rated negative-symptom improvements in a small schizophrenia spectrum disorder pilot trial. Key Findings Oxytocin arm showed the main signal: The OXYMIND pilot assigned 26 outpatients to oxytocin plus mindfulness-based group therapy and …

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Phobic Anxiety Predicted Depression Treatment Response in Self-Report Study

Phobic Anxiety Predicted Depression Treatment Response in Self-Report Study

TL;DR: A 2026 longitudinal study in Journal of Korean Medical Science found that self-reported phobic anxiety on the Symptom Checklist-90-Revised helped predict 2-month depression treatment response even when baseline clinician-rated depression and anxiety scores were similar. Key Findings Mood-disorder cohort was followed: The cohort included 157 people with major depressive disorder or bipolar disorder who …

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Depression Reduced Alpha-Beta Reward Signaling in Movement Disorder Patients

Depression Reduced Alpha-Beta Reward Signaling in Movement Disorder Patients

TL;DR: A 2026 study in eNeuro used intracranial electroencephalography (EEG), a recording method for brain electrical activity, during deep brain stimulation surgery and found that Parkinson’s disease and essential tremor patients with elevated depression symptoms had weaker corticostriatal alpha-beta reward signaling. Key Findings 30 DBS patients participated: The sample included 14 Parkinson’s disease patients and …

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CBT Online Self-Help Group Reduced Depression Symptoms in RCT

CBT Online Self-Help Group Reduced Depression Symptoms in RCT

TL;DR: A 2026 randomized trial in JMIR mHealth and uHealth found that a 7-session CBT-based online self-help group reduced depression symptoms, with the average Beck Depression Inventory-II score moving from the moderate range to the mild range after the program. Key Findings Depression scores decreased: The CBT-based online self-help group fell from a mean BDI-II …

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