TL;DR: A 2026 study protocol in PLOS One describes a planned longitudinal study that will track academic stress, depressive symptoms, diet, sleep-related wearable measures, salivary cortisol, and other health indicators across a university semester, but it does not yet report outcome results. Key Findings Study protocol only: The source describes the planned design and hypotheses; …
TL;DR: A 2026 cross-sectional study in PLOS One found that people with post COVID-19 condition reported worse quality of life, fatigue, sleep, psychological wellbeing, and subjective cognition than COVID-19 survivors without the condition, while many objective lung, metabolic, and cognitive tests did not differ. Key Findings 139-person Dutch cohort: The study included 87 people with …
TL;DR: A 2026 preprint in medRxiv analyzed plasma proteomics in Alzheimer’s disease and mild cognitive impairment and found that four continuous molecular axes described the data better than hard subtype labels. Key Findings 5,895-person AD/MCI sample: The discovery analysis used one record per participant from the Global Neurodegeneration Proteomics Consortium. 81.5% module-space variance: Four continuous …
TL;DR: A 2026 preprint in medRxiv warned that a standard Alzheimer’s disease biomarker-clock analysis can create a countdown paradox, where later biomarker-clock ages appear linked to faster mild cognitive impairment onset because of the way remaining time is calculated. Key Findings 100% false positives in simple null simulations: The standard countdown analysis rejected the null …
TL;DR: A 2026 review in Brain Medicine found mixed randomized-trial evidence for creatine monohydrate as an add-on depression treatment: 2 of 5 trials showed symptom benefits, while 3 did not find a clear advantage. Key Findings Five randomized trials were reviewed: The review summarized 238 baseline participants across trials of creatine monohydrate for mood disorders. …
TL;DR: A 2026 review and activation-likelihood estimation study in European Journal of Pain found that the dorsolateral prefrontal cortex (dlPFC), a frontal control region, was repeatedly engaged in acute pain, chronic pain, and placebo analgesia, mainly across Brodmann areas 8, 9, and 46. Key Findings 138 studies included: The review screened 4810 deduplicated records and …
TL;DR: A 2026 study in Signal Transduction and Targeted Therapy engineered a modified inhibitory DREADD receptor called GRANPA so the over-the-counter antihistamine diphenhydramine could switch off targeted brain circuits and reduce seizure activity in mouse models. Key Findings Two added receptor mutations: The lead GRANPA receptor combined hM4Di with S85V and Y416F mutations to improve …
TL;DR: A 2026 study in Psychological Medicine found that sleep quality partly explained how early adolescent depression, anxiety, and psychotic-like experience distress were linked to later school grades and social problems in the Adolescent Brain Cognitive Development Study. Key Findings Scale: Researchers analyzed 6,754 adolescents with grade data and 7,550 adolescents with social-problems data across …
TL;DR: A 2026 observational study in International Journal of Legal Medicine found that cocaine dominated analytically confirmed recreational drug toxicity cases in one Bologna emergency department, while ketamine was common and all new-psychoactive-substance-positive patients had psychomotor agitation. Key Findings 110 ED patients: The observational study enrolled 110 patients with suspected acute recreational drug toxicity between …
TL;DR: A 2026 systematic review and meta-analysis in Journal of Medical Internet Research found that immersive virtual reality reduced anxiety and pain in randomized trials of gastrointestinal cancer care, but wide prediction intervals and low evidence certainty mean the effect may vary across clinical settings. Key Findings 14 RCTs: The review included 14 randomized controlled …
