PTSD

Medical Cannabis for Anxiety, PTSD, and Sleep: Cannabinoid Evidence Remains Weak

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Cannabinoids Had Weak Evidence for Mental Disorders

Cannabinoids Had Weak Evidence for Mental Disorders TL;DR: A Lancet Psychiatry review of randomized trials found little support for routine cannabinoid treatment in common mental disorders, despite possible weak signals in a few narrower conditions. Key Findings 54 randomized controlled trials were reviewed: The analysis covered 2,477 participants across mental disorders and substance-use disorders. Routine …

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Amygdala Astrocytes Helped Store and Extinguish Fear Memories

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How Astrocytes Help the Amygdala Store Fear Memories

How Astrocytes Help the Amygdala Store Fear Memories TL;DR: Amygdala astrocytes were not passive support cells: their calcium signals tracked learned fear states and were required for neuronal fear-memory representations in mice. Key Findings In vivo BLA imaging across multiple mouse cohorts: The team combined astrocyte and neuronal calcium imaging, electrophysiology, and circuit manipulations in …

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1 in 5 Trauma-Exposed Children Met PTSD Criteria in 2025 Meta-Analysis

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How Often Trauma-Exposed Kids Develop PTSD Now

How Often Trauma-Exposed Kids Develop PTSD Now TL;DR: An updated meta-analysis of 95 studies found that about 1 in 5 trauma-exposed children met DSM-IV PTSD criteria and about 1 in 8 met DSM-5 criteria, with the highest rates in girls and in youth exposed to interpersonal trauma. Key Findings 95 studies over 30 years: The …

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Childhood Trauma Increased Randomness in Teen Depression Brain Networks

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Childhood Trauma Made Teen Depression Networks More Random

Childhood Trauma Made Teen Depression Networks More Random TL;DR: In 343 adolescents with major depression, childhood trauma was linked to less efficient brain-network organization, partial normalization after treatment, and an fMRI-based model that predicted antidepressant response with 82% balanced accuracy. Key Findings 343 depressed adolescents scanned: The study analyzed resting-state functional MRI (fMRI) in adolescents …

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Psychological Trauma & Adversity May Accelerate Biological Aging (2024 Analysis)

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Adversity accelerates biological aging through health-compromising behaviors like smoking and possibly social disconnection, and future research needs to focus on causal methodologies to better understand these processes and develop effective interventions. Highlights: Mechanisms of Accelerated Aging: Recent studies suggest that adversity accelerates biological aging, with health-compromising behaviors, especially smoking, playing a significant role in this …

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Virtual Reality Exposure Therapy (VRET) for Car Accident PTSD: A Promising Intervention

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Posttraumatic stress disorder (PTSD) following a traumatic event like a car accident can be extremely debilitating. New research suggests that virtual reality exposure therapy (VRET) may be an effective treatment option. Key Facts VRET is a form of exposure therapy that uses virtual reality to simulate the traumatic experience in a controlled setting. Two case …

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MDMA Assisted Therapy for Alcohol Abuse & PTSD

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A new study provides preliminary evidence that MDMA-assisted therapy may help reduce alcohol use in people with severe PTSD. Key facts: MDMA-assisted therapy was tested in a phase 3 clinical trial for treating severe PTSD. Participants were allowed to have mild alcohol or cannabis use disorder. Compared to placebo therapy, MDMA therapy led to greater …

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