TL;DR: A 2026 article-in-press study in Alzheimer’s Research & Therapy found that olfactory-region MRI radiomics, a method that turns brain scans into quantitative texture and shape features, linked blood pTau217, a tau-related Alzheimer’s disease biomarker, with cognitive impairment across three cohorts. Key Findings Three Alzheimer’s cohorts were matched: Researchers matched 122 Alzheimer’s disease (AD) patients …
TL;DR: A 2026 machine-learning study found that the final SNP-NF model in PLOS One reported mAUC 0.965, recall 0.929, and precision 0.929, while the study reported gains of about 3% in mAUC, 1% in precision, and 0.7% in recall versus their previous neural-process model. Key Findings SNP-NF performance was high: The final model reported mAUC …
TL;DR: A 2025 study in Neurochemistry International from Kindai University showed that oral arginine, a naturally occurring amino acid, blocked the formation of toxic amyloid-beta aggregates in lab tests and reduced amyloid pathology in two well-established mouse models of Alzheimer’s disease — with the authors flagging that the research-grade doses and methods are not equivalent …
TL;DR: A 2026 randomized crossover trial in Cell Metabolism compared natural daylight against standard artificial office lighting in 13 older adults with well-controlled type 2 diabetes and found that natural-daylight days produced more time in a healthy blood-glucose range (about 51% vs 43%), smaller glucose swings, and a metabolic shift toward burning more fat and …
TL;DR: A 2026 study in the Journal of the American Heart Association followed 1,882 stroke-free women from the Framingham Heart Study for a median of 18 years and found that having three or more live births was associated with a reduced risk of clinical stroke and lower MRI markers of vascular brain injury — the …
TL;DR: A 2026 systematic review in The Cochrane Database of Systematic Reviews pooled 17 trials of anti-amyloid monoclonal antibodies (N=20,342 people with mild cognitive impairment or mild Alzheimer’s dementia) and concluded that any effect on memory decline or dementia severity was either nonexistent or well below the threshold considered clinically meaningful for patients. Key Findings …
TL;DR: A 2026 Mendelian randomization study in Progress in Neuro-Psychopharmacology & Biological Psychiatry used genetic data to test direction of effect between brain structure and neurodevelopmental conditions, and found that increased surface area in the superior frontal gyrus raised ADHD risk while increased surface area in the orbital frontal gyrus protected against autism — with …
TL;DR: A 2026 Communications Biology fMRI study found that language and theory of mind, the ability to infer other people’s mental states, were already neurally distinct in children aged 3-9 rather than slowly separating during development. Key Findings Children show distinct neural specificity for language and theory of mind in superior temporal lobe — just …
TL;DR: A 2024 Gastroenterology study found that intestinal epithelial serotonin reduced anxiety- and depression-like behavior in mice through vagal signaling, while prenatal SSRI exposure in a human cohort predicted infant functional constipation independent of maternal depression. Key Findings Gut-only serotonin reuptake transporter ablation reduced anxiety and depression-like behavior: Targeting SERT only in the intestinal epithelium …
TL;DR: A 2026 mouse study in iScience found that anesthetic emergence slowed sharply below 31.9°C because two hypothalamic thermoregulatory pathways pushed anesthesia in opposite directions: preoptic BDNF neurons deepened anesthesia, while a dorsomedial-hypothalamus-to-raphe-pallidus glutamate pathway accelerated emergence. Key Findings Emergence delay grows logarithmically below 31.9°C core temperature: In mice, anesthetic emergence time increases logarithmically as …
