Neuroscience

GLP-1 Agonists Showed Dose-Specific ON-Medication Motor Effects in Parkinson’s Disease

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GLP-1 Agonists Showed Dose-Specific ON-Medication Motor Effects in Parkinson's Disease

TL;DR: A 2026 systematic review and exploratory network meta-analysis of 5 randomized trials in Neurological Sciences found dose-specific ON-medication motor improvements, measured while usual Parkinson’s drugs were active, for some GLP-1 receptor agonists, glucose-related metabolic hormone drugs, in Parkinson’s disease, but broader motor, non-motor, and quality-of-life evidence remained limited. Key Findings 5 randomized trials: The …

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Antipsychotic D2 Blockade May Disturb Pancreatic Insulin Secretion

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Antipsychotic D2 Blockade May Disturb Pancreatic Insulin Secretion

TL;DR: A 2026 systematic review and meta-analysis in Neuropsychopharmacology found that dopamine D2-like receptor activation suppressed glucose-stimulated insulin secretion (GSIS), insulin release after high glucose, in animal pancreatic cells, suggesting one peripheral route by which antipsychotic dopamine blockade can disturb glucose control beyond weight gain. Key Findings 39 eligible studies: Researchers screened 12,457 citations and …

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Half of 292 Adult ADHD Randomized Trials Skipped a General Psychopathology Assessment, Scoping Review Found

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Half of 292 Adult ADHD Randomized Trials Skipped a General Psychopathology Assessment, Scoping Review Found

TL;DR: A 2025 scoping review in European Psychiatry screened 292 randomized trials of adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) and reported that 49.7% did not assess general psychopathology and only 35% had the ADHD diagnosis allocated by a psychiatrist or psychologist. Key Findings Half of the trials skipped a general psychopathology check: 49.7% of the …

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25C-NBF, a Selective 5-HT2A Phenethylamine, Reduced Despair and Restored Sucrose Preference in Male Mice

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25C-NBF, a Selective 5-HT2A Phenethylamine, Reduced Despair and Restored Sucrose Preference in Male Mice

TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the prefrontal cortex, and showed no rewarding or reinforcing properties at the tested doses. Key Findings Despair behavior fell after …

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Targeted Memory Reactivation Changed Sleep Waves But Not Motor Retention in Parkinson’s

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Targeted Memory Reactivation Changed Sleep Waves But Not Motor Retention in Parkinson’s

TL;DR: A 2026 medRxiv preprint found that targeted memory reactivation (TMR), replaying learned sounds during non-REM sleep, changed spindle and slow-wave density during a nap but did not improve motor memory retention in Parkinson’s disease or healthy older adults. Key Findings Parkinson’s and healthy older adults were compared: The experiment included 20 people with Parkinson’s …

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Post-Stroke Depression Linked to Serotonin and Acetylcholine Network Damage

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Post-Stroke Depression Linked to Serotonin and Acetylcholine Network Damage

TL;DR: A 2026 medRxiv preprint linked post-stroke depressive symptoms to stroke damage in serotonin-transporter and acetylcholine-transporter weighted brain networks, suggesting depression risk after stroke may depend partly on which neurochemical circuits a lesion disrupts. Key Findings 435 stroke patients analyzed: Researchers combined two independent cohorts, Leipzig and Oxford, after exclusions for missing clinical variables and …

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NDST3 Suppression Restored Lysosomal Acidification in Alzheimer’s Models

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NDST3 Suppression Restored Lysosomal Acidification in Alzheimer’s Models

TL;DR: A 2026 study in Translational Neurodegeneration found that reducing NDST3, a microtubule deacetylase that affects lysosome acidity, restored lysosomal acidification and reduced amyloid-beta and tau pathology in Alzheimer’s cell and mouse models. Key Findings Lysosomal pH shifted back: APP695Swe-overexpressing HT22 cells had lysosomal pH near 5.6, while Ndst3 knockdown lowered it to less than …

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Image Memorability Predicted N400 Encoding Signals More Than Recognition

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Image Memorability Predicted N400 Encoding Signals More Than Recognition

TL;DR: A 2026 study in Cognitive, Affective, & Behavioral Neuroscience found that image memorability, the stable tendency of an image to be remembered across people, predicted N400 brain responses at encoding even after later recognition success was modeled. Key Findings 24 analyzed participants: Researchers recorded event-related potentials (ERPs), scalp-measured brain responses time-locked to image viewing, …

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Dexamethasone Disrupted Mouse Sleep Through Orexin Activation

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Dexamethasone Disrupted Mouse Sleep Through Orexin Activation

TL;DR: A 2026 mouse study in Psychopharmacology found that repeated dexamethasone, a synthetic glucocorticoid steroid, disrupted light-phase sleep and increased orexin-neuron activity, a wake-promoting hypothalamic signal, during sleep-to-wake transitions. Key Findings 5-day steroid model: Male C57BL/6J mice received dexamethasone at 30 mg/kg for 5 days before 24-hour sleep recording. Light-phase sleep was disrupted: Dexamethasone increased …

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BIOMEDE Trial Found No Survival Gain From Targeted Drugs in DIPG

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BIOMEDE Trial Found No Survival Gain From Targeted Drugs in DIPG

TL;DR: A 2026 randomized phase 2 trial in Nature Medicine found that three targeted drugs added to radiotherapy did not improve overall survival for children with diffuse intrinsic pontine glioma (DIPG), a lethal brainstem tumor, although everolimus caused fewer treatment-stopping side effects. Key Findings 233 randomized patients: BIOMEDE assigned 36 children to erlotinib, 102 to …

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