Neurotech

Subgaleal ISP Stimulation Reduced Treatment-Resistant Epilepsy Seizures

June 7, 2026 by BrainASAP

TL;DR: A 2026 medRxiv preprint reported that closed-loop subgaleal intersectional short-pulse stimulation reduced seizure duration and rapidly lowered seizure incidence in a small first-in-human treatment-resistant epilepsy study. Key Findings Subgaleal implantation reached 13 patients: Researchers enrolled 15 adults, 2 withdrew before implantation, and 13 underwent subgaleal electrode implantation and inpatient monitoring. 2,283 hours of video-EEG …

MoS2 Artificial Neurons Triggered Responses in Living Brain Slices

May 27, 2026 by BrainASAP

TL;DR: A 2026 study in Nature Nanotechnology reported that printed MoS2 memristive nanosheet networks, electronic devices that can produce neuron-like spikes, triggered responses in living mouse brain slices. Key Findings Artificial spiking neurons: Researchers built printed MoS2 memristive nanosheet networks that generated electrical activity resembling neural spikes. Living-tissue response: In mouse brain-slice experiments, the artificial …

Home DBS Recordings Tracked Depression Recovery Biomarkers

May 24, 2026 by BrainASAP

TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuations and external distress. Key Findings Study type: a home-recording study using bidirectional deep brain stimulation devices to monitor electrophysiology during depression recovery. …

Cheese3D Six-Camera System Tracked Whole-Mouse-Face 3D Motion at Sub-Millimeter Precision

May 18, 2026 by BrainASAP

TL;DR: A 2026 methods paper in Nature Neuroscience introduced Cheese3D, a six-camera system that tracked whole-mouse-face movement in 3D at sub-millimeter precision and used facial dynamics to infer anesthesia depth and neural-state-linked expression. Key Findings Sub-millimeter 3D tracking of the whole mouse face: Cheese3D uses a calibrated 6-camera array to capture motion of ears, eyes, …

Connectome-seq Maps Brain Wiring With RNA Barcodes at Single-Synapse Resolution

May 15, 2026May 8, 2026 by BrainASAP

Connectome-seq Turned Synapses Into Barcodes TL;DR: Connectome-seq is a 2026 Nature Methods platform that maps brain wiring by combining engineered synaptic proteins, RNA barcodes, single-nucleus sequencing, and single-synaptosome sequencing. In a mouse pontocerebellar circuit, the method linked synaptic connections to the molecular identities of connected neurons, turning a wiring map into something sequencing can read. …

ECT Was Not Linked to Long-Term Dementia Harm in Adjusted Data

May 15, 2026May 7, 2026 by BrainASAP

ECT Looks Safer in the Long Run Than Its Reputation TL;DR: A British Journal of Psychiatry review argues that modern population-level studies do not support a long-term increase in dementia or major cardiovascular risk after electroconvulsive therapy and instead point toward lower suicide mortality and all-cause mortality in the patients who receive it. Key Findings …

Focused Ultrasound Reprogrammed Microglia in Alzheimer’s Rats

May 15, 2026May 6, 2026 by BrainASAP

How Focused Ultrasound Reprogrammed Microglia in Alzheimer’s Rats TL;DR: In TgF344-AD rats, repeated low-intensity focused ultrasound triggered a short-lived inflammatory response, then left behind a more durable microglial metabolic shift in early disease without clearly improving Alzheimer’s pathology on its own. Key Findings 450 kPa across a 12 x 6 mm target: The team skull-corrected …

Low CSF Ethanolamine Linked to Major Depression, Levels Increase After ECT

May 15, 2026May 6, 2026 by BrainASAP

Ethanolamine Could Be a Depression Biomarker and Treatment Target

Ethanolamine Looked Like a Depression Biomarker and Treatment Target TL;DR: In a 380-person cerebrospinal fluid dataset, patients with active major depression had lower ethanolamine levels than controls, those levels rose after electroconvulsive therapy, and parallel rat experiments suggested the molecule may be more than just a marker. Key Findings 380-person cerebrospinal fluid (CSF), the fluid …

DLPFC-sgACC EEG Connectivity Predicted rTMS Remission in Depression

May 15, 2026May 6, 2026 by BrainASAP

Brain Circuit Signal Predicted rTMS Remission

DLPFC-sgACC Circuit Signal Predicted rTMS Remission TL;DR: Before starting rTMS, patients who later remitted from depression showed lower alpha-band connectivity flowing from the DLPFC to the subgenual cingulate — pointing toward a measurable EEG marker that could help select candidates before weeks of treatment are spent. Key Findings Remitters had lower pre-treatment DLPFC-to-sgACC alpha connectivity: …

Whole-Spinal-Cord MRI Could Detect Silent MS Lesions Missed by Brain MRI

May 15, 2026May 4, 2026 by BrainASAP

Spinal Cord MRI Could Change Early MS Follow-Up

Spinal Cord MRI Could Change Early Multiple Sclerosis Follow-Up TL;DR: Routine MS monitoring focuses on the brain — but prior data suggest 12% of new spinal cord lesions appear with no simultaneous brain activity. The MSpine trial is now testing whether systematic whole-spine MRI catches disease that standard follow-up is missing. Key Findings 31.2% of …

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