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TL;DR: A 2026 rat study in Neuropsychopharmacology found that PACAP/PAC1 signaling in the lateral septum changed forced-swim coping, ACTH stress-hormone release, open-arm exploration, and grooming behavior. Key Findings Stress changed PACAP signals by brain re…
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TL;DR: A 2026 Psychological Medicine meta-analysis of 109 studies linked parental severe mental illness, especially schizophrenia and bipolar disorder, to lower cognitive performance in offspring across IQ, language, memory, executive function, and general cog…
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TL;DR: A 2026 case-series study in Translational Psychiatry tested delayed-release oral acetate from apple cider vinegar capsules in 11 young adults taking psychotropic medications and found high adherence, no product-related adverse events, microbiome shifts,…
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TL;DR: A 2026 study in The Journal of Neuroscience found that listening to consonant chord progressions while looking at a live partner increased functional near-infrared spectroscopy (fNIRS), a scalp blood-flow measure, in social brain systems. Key Findings D…
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TL;DR: A 2026 mouse study in Cell traced ketamine’s rapid antidepressant-like effect to mu-opioid receptors on somatostatin-positive interneurons in the medial prefrontal cortex. Low-dose multi-GPCR targeting reproduced ketamine-like effects in mice, but the e…
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TL;DR: A 2026 biomarker analysis in Brain, Behavior, & Immunity – Health across antidepressant trials found that kynurenine pathway metabolites were elevated in inflammatory depression compared with non-inflammatory depression and healthy controls, while omega…
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TL;DR: A 2026 cross-sectional NHANES analysis in Depression and Anxiety found that urinary pyrethroid metabolite 3-PBA showed a dose-dependent association with depression, while female participants showed stronger associations for 3-PBA and 4F-3-PBA, while mal…
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TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuat…
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TL;DR: A 2026 PTSD neuroimaging and language-analysis study in Neuropsychopharmacology found that hippocampal activity encoded specific semantic content of traumatic and neutral autobiographical memories, while greater hippocampal sensitivity to autobiographic…
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TL;DR: A 2026 Nature Communications study found that mouse hippocampal CA3 connectivity shifts from dense-random early wiring to sparse-structured adult wiring, with weaker single synapses that make memory-network output depend on coordinated input rather than…
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