PTP1B Inhibition Reduced Amyloid-Beta in Alzheimer’s Mice
TL;DR: A 2026 mouse study in Proceedings of the National Academy of Sciences found that deleting or inhibiting PTP1B improved memory behavior, reduced amyloid-beta burden, and pushed microglia toward an amyloid-clearing state. Key Findings Memory behavior improved: APP/PS1 mice lacking PTP1B performed better in novel object recognition and Morris water maze tests; the PTP1B inhibitor …
