TL;DR: A new study reveals that impaired cerebrovascular function—the brain’s ability to regulate blood flow—correlates strongly with Alzheimer’s symptoms, offering a potential non-invasive way to detect early cognitive decline. Alzheimer’s disease has long been framed as a problem of toxic protein accumulation: amyloid plaques and tau tangles strangling neurons into silence. But what if the …
TL;DR: Blocking DUSP6 protein alongside ketamine extends antidepressant effects from 2 weeks to 4+ weeks in mice, potentially offering single-dose treatment instead of repeated infusions. Ketamine works like almost nothing else in psychiatry. A single infusion can lift severe depression within hours, even in patients who’ve failed every other drug. The problem? The magic doesn’t …
TL;DR: The brain stores content (what you remember) and context (when/where) in separate neural populations linked by real-time coordination, not pre-wired conjunctive cells—a design that trades speed for flexibility, allowing you to recognize a friend’s face across any setting or apply a principle learned once to infinitely new situations. For forty years, neuroscientists thought memory …
TL;DR: Cocaine hijacks a transcription factor called FosB in a brain circuit connecting the hippocampus to the nucleus accumbens, suppressing neural excitability and driving compulsive drug-seeking behavior—a mechanism that could reshape addiction treatment. The brain has two competing drives during addiction: the conscious desire to quit and the limbic system’s relentless pull toward the drug. …
A study found shared brain-specific mechanisms between Alzheimer’s disease (AD) and depression, particularly involving synaptic signaling and immune system pathways in the hippocampus, but no direct genetic overlap. Highlights: Six brain-specific eQTL genes (SRA1, MICA, PCDHA7, PCDHA8, PCDHA10, PCDHA13) are shared between AD and depression. Pathway analysis identified shared biological pathways, including synaptic signaling, myelination, …
This study shows that type 2 diabetes causes decreased blood flow and changes in neural activity in specific parts of the hippocampus, which may initially compensate for cognitive decline but deteriorate with worsening diabetes. Highlights: Decreased Perfusion: Patients with type 2 diabetes have lower blood flow in the right hippocampal CA1, DG, and subiculum areas. …
A new study provides evidence that the psychedelic compound psilocybin has both immediate and lasting anti-inflammatory effects in healthy volunteers. The findings shed light on how psilocybin may improve mood, social behavior, and potentially treat depression. Key facts: Psilocybin decreased the inflammatory marker TNF-alpha immediately after administration. Seven days later, psilocybin reduced two other inflammatory …
Researchers have discovered that a common soil bacterium called Mycobacterium vaccae (M. vaccae) may help reduce stress, anxiety, and inflammation in the brain. Key Facts: M. vaccae is a naturally occurring bacterium found in soil, mud, and water. It is considered harmless to humans. When heat-killed M. vaccae is injected into rats, it reduces stress-induced …
Depression and cognitive deficits are common health issues that impact millions of people. Scientists are testing a new drug, NSI-189, to see if it can help treat depression and improve thinking ability. Early research shows promise that NSI-189 may be able to grow new brain cells and connections, which could potentially treat depression and boost …
The neurotransmitter serotonin plays many important roles in our brains and bodies by binding to various serotonin receptor proteins. One of these receptors, called 5-HTR1E, has remained mysterious even after its discovery over 30 years ago. Facts about 5-HTR1E receptor: It is one of the 13 known serotonin receptor proteins that serotonin can bind to …
