MRI Microstructure Predicted Impulse-Control Change After Parkinson’s DBS

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MRI Microstructure Predicted Impulse-Control Change After Parkinson's DBS

TL;DR: A 2026 medRxiv preprint linked pre-surgery diffusion MRI markers in Parkinson’s disease to 6-month changes in impulsive-compulsive behaviour after subthalamic deep brain stimulation. Key Findings Small DBS cohort: Researchers followed 35 Parkinson’s disease patients from preoperative diffusion MRI to 6-month clinical follow-up after subthalamic deep brain stimulation. Behaviour score: Impulsive-compulsive behaviour was measured with …

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Self-Localized Pencil Beam Improved 3D Multiphoton BBB Imaging

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Self-Localized Pencil Beam Improved 3D Multiphoton BBB Imaging

TL;DR: A 2026 Nature Methods paper described a self-localized ultrafast pencil beam that made volumetric multiphoton imaging faster and more stable, including 1-minute 3D scans of transferrin uptake in a live human blood-brain barrier model. Key Findings Optics advance: A standard multimode fiber produced a stable, sidelobe-suppressed Bessel-like pencil beam near critical power. Microscopy fit: …

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Organophosphate Exposure Linked to Delayed Neuropathy in Case Report

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Organophosphate Exposure Linked to Delayed Neuropathy in Case Report

TL;DR: A 2026 study in Journal of Medical Case Reports described organophosphate-induced delayed neuropathy (OPIDN), a delayed nerve-injury syndrome, in a 44-year-old pesticide applicator after years of low-level exposure without a typical acute poisoning crisis. Key Findings 9-year exposure history: The patient had worked with chlorpyrifos, malathion, and diazinon for years, often 6-9 hours daily …

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Orbitofrontal PV Interneurons Reduced Social Behavior via DMN Connectivity

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Orbitofrontal PV Interneurons Reduced Social Behavior via DMN Connectivity

TL;DR: A 2026 mouse study in Communications Biology found that activating parvalbumin (PV) interneurons, inhibitory nerve cells in the orbitofrontal cortex, reduced default mode network connectivity and decreased normal social approach and sniffing behavior. Key Findings PV interneurons were targeted: Researchers used PV-Cre mice and a chemogenetic DREADD receptor to activate inhibitory PV interneurons in …

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Open ICU Visiting Linked to Lower Delirium and Anxiety Scores

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Open ICU Visiting Linked to Lower Delirium and Anxiety Scores

TL;DR: A 2026 retrospective ICU study in the International Journal of General Medicine found that 24-hour open visiting was associated with lower delirium incidence and lower anxiety/depression scores than 1-hour restricted visiting in chronic critically ill patients. Key Findings 264 ICU patients: The retrospective cohort included 132 restricted-visiting patients and 132 open-visiting patients. 24-hour access: …

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Nicotine Dependence Linked to Lower ICU COVID-19 Mortality in Texas Cohort

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Nicotine Dependence Linked to Lower ICU COVID-19 Mortality in Texas Cohort

TL;DR: A 2026 study in PLOS One found that Texas ICU COVID-19 hospitalizations coded for current nicotine dependence had lower crude and adjusted mortality than hospitalizations coded as never nicotine dependent, but the administrative-data design means the result should not be read as evidence that nicotine is protective. Key Findings Large ICU cohort: Researchers analyzed …

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Acculturative Stress Predicted Depression and Anxiety in International Students

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Acculturative Stress Predicted Depression and Anxiety in International Students

TL;DR: A 2026 study in BMC Psychology found high rates of depression, anxiety, and recent self-harm thoughts among international students in Germany, with acculturative stress linked to worse mental health and mindfulness, optimism, self-efficacy, acceptance, and social support linked to lower symptom burden. Key Findings Depression and anxiety were common: 46.5% of the 327 international …

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Natural Images and White Noise Changed What People Saw in Pareidolia

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Natural Images and White Noise Changed What People Saw in Pareidolia

TL;DR: A 2026 Scientific Reports study found that natural images and white noise images produced similar amounts of pareidolia, but they shifted what people thought they saw. Key Findings Healthy adult sample: The study included 81 participants who viewed ambiguous images and drew every illusory object, face, figure, or pattern they perceived. Equal quantity: The …

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MK-8189 PDE10A Inhibitor Failed Schizophrenia Phase 2b PANSS Endpoint

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MK-8189 PDE10A Inhibitor Failed Schizophrenia Phase 2b PANSS Endpoint

TL;DR: A 2026 randomized phase 2b trial in Journal of Clinical Psychopharmacology found that the PDE10A inhibitor MK-8189 did not improve Positive and Negative Syndrome Scale (PANSS) schizophrenia symptom scores more than placebo after 6 weeks, while risperidone separated from placebo in the same trial. Key Findings 458 treated participants: The acute phase included 132 …

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