Parental Inbreeding (Consanguinity) Increases Risk of Schizophrenia (South India Study)

A new study conducted in rural South India has found that people whose parents are blood relatives (consanguineous marriage) have an increased risk of developing schizophrenia compared to the general population. Key Facts: Researchers recruited 120 patients with schizophrenia and 222 healthy controls from the same rural region in South India. 10.7% of patients with …

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Genetics & Intelligence (IQ): How DNA Shapes Cognition, Problem Solving, etc.

Our genes influence more than just our raw intelligence and problem-solving abilities. The latest discoveries in the genetics of intelligence are showing how our DNA shapes how we learn, our educational attainment, occupational success, and even our health outcomes. Genetic research is revealing the deep connections between inherited cognitive capacities and multiple aspects of life. …

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Biological Roots of Criminal Behaviors: Physiology, Brain Structure & Function, Genetics

Criminal behavior has complex origins. While social and psychological factors play a clear role, a growing body of research suggests biological factors also influence criminality. Here’s what the science says so far about the biology underlying criminal behavior. Key Facts: Genetics account for 40-60% of variance in antisocial behavior. Environmental factors also play a role. …

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Pharmacogenomics: Genetics Determine Weight Gain & Loss from Drugs & Medications

Obesity has reached epidemic levels globally, with serious health and economic consequences. While lifestyle factors play a key role, genetics also influence a person’s susceptibility to weight gain or difficulty losing weight. An emerging field called pharmacogenomics is uncovering how genetics impacts response to medications that cause weight gain as a side effect, as well …

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Phthalates May Modify Epigenetics: Long-Term, Multi-Generational Effects

Phthalates, a class of chemicals used to make plastics more flexible and durable, may impact health across multiple generations. New research suggests phthalate exposure in one generation can lead to adverse effects in subsequent generations through changes in gene regulation. This raises concerns that the public health impacts of phthalates may be more extensive than …

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CRISPR for Alzheimer’s Disease: Future Treatment via Gene Editing

Alzheimer’s disease continues to destroy minds, but new gene editing techniques like CRISPR offer hope for better understanding and treating this devastating illness. Key Facts: Alzheimer’s disease is a complex, poorly understood neurodegenerative disorder affecting over 50 million people worldwide. Gene mutations play a role in early-onset Alzheimer’s, but late-onset Alzheimer’s involves a more complex …

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Modafinil & Sleep Homeostasis: Effects Determined By COMT Gene Variants

New research reveals that the wake-promoting drug modafinil affects markers of sleep homeostasis differently depending on a person’s genetics. Key facts: Modafinil improved sustained attention in people with a certain gene variant but not others after sleep deprivation. Modafinil reduced sleepiness and theta brain waves during wakefulness regardless of genetics. Modafinil did not reduce slow …

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Genetic DNA Mutations in Human Population: Simulation Suggests Beneficial Genes Offset Decline

Humans and other complex organisms face a constant barrage of new harmful genetic mutations, yet somehow manage to persist and evolve despite this mutational load. New research reveals how populations can survive this onslaught through a delicate balancing act between bad and good mutations. Key Facts: Each person inherits around 2-10 new harmful mutations from …

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Genetics Linked to Intelligence (IQ), Health, Longevity: Polygenic Scores

Intelligence predicts health and mortality – but why? New research reveals some genes are implicated in both. Key facts: Intelligence test scores predict mortality, illnesses, and health behaviors. Higher scores indicate lower risk. Both intelligence and health/disease outcomes are highly polygenic – many genetic variants of small effect contribute. Genetic correlations exist between intelligence and …

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Genetics & Specific Cognitive Abilities: Highly Heritable (50%)

General intelligence, known as g or IQ, has long been the focus of cognitive genetics research. But what about more specific cognitive abilities, the building blocks that make up IQ? A sweeping new meta-analysis of over 740,000 twins surprisingly suggests: Specific cognitive abilities (SCA) like reading, math and processing speed are just as heritable as …

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