TL;DR: A 2026 study in Neuron found that glioblastoma was not growing alone: reactive oligodendrocytes helped maintain glioma stem cells through CCL5/CCR5 signaling, and blocking that conversation slowed tumor growth in models. Key Findings CCL5/CCR5 showed the association: Reactive oligodendrocytes promoted glioma stem cell maintenance through a chemokine pathway better known from immune biology. Stem-like …
TL;DR: A 2026 randomized clinical trial in the Journal of Sport and Health Science assigned 130 midlife adults to 150 minutes/week aerobic exercise or no-exercise control for 1 year and found sustained lower long-term cortisol in the exercise group. Key Findings Year-long randomized trial in 130 midlife adults: Participants aged 26 to 58 were randomly …
TL;DR: A 2026 preprint in medRxiv used 18F-DOPA positron emission tomography (PET) to estimate dopamine synthesis and storage, and found that caudate dopamine synthesis decreased as schizophrenia patients moved from active psychosis into early psychotic remission. Key Findings Patient group: Researchers scanned 28 schizophrenia patients twice and compared them with 21 healthy controls scanned over …
TL;DR: A 2026 randomized study in Psychological Medicine found that right orbitofrontal cortex repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain-stimulation method, improved visuospatial memory on the Brief Visuospatial Memory Test-Revised (BVMT) in people with first-episode schizophrenia. Key Findings The analysis included 90 patients: Researchers studied 48 people assigned to active rTMS and 42 assigned …
TL;DR: A 2026 functional MRI (fMRI) study in Translational Psychiatry found that counterconditioning, a form of exposure learning that replaces a threat cue with a positive outcome, strengthened safety-memory signals in adults with PTSD more than standard extinction did. Key Findings Safety learning was tested: Researchers studied 54 adults, including 32 with post-traumatic stress disorder …
TL;DR: A 2026 npj Parkinson’s Disease study used brain transcriptome data and genome-scale metabolic modeling to predict Parkinson’s metabolite biomarkers, including dopamine-related changes, and separated 104 postmortem samples into three metabolic clusters. Key Findings Metabolic model: The study used TAMBOOR, a transcriptome-based metabolic modeling algorithm, to predict metabolite oversecretion and undersecretion. Brain tissue data: The …
TL;DR: A 2026 systematic review and meta-analysis in Acta Neuropsychiatrica found no clear evidence that parenteral clomipramine is better than oral clomipramine for depression or obsessive-compulsive disorder, with low or very low certainty across the main randomized-trial evidence. Key Findings 4,973 publications screened: The review identified 14 randomized controlled trials relevant to parenteral clomipramine in …
TL;DR: A 2026 cross-sectional study in Psychiatry Research surveyed 558 Palestinian refugees displaced to Egypt after the 2023 Gaza war and used Bayesian network analysis to map their psychological symptoms; suicidal ideation emerged as the central hub for both men and women, with secondary core symptoms differing by gender (loss of energy in men, psychomotor …
TL;DR: A 2026 secondary randomized-trial analysis in Journal of Medical Internet Research found that both online MBCT formats reduced psychological distress and improved well-being through 9 months, while people with fewer psychological resources appeared to gain larger benefits. Key Findings Study type: a long-term follow-up of two online mindfulness-based cognitive therapy formats for people with …
TL;DR: A 2026 preprint neurosurgery neuroplasticity study in medRxiv found that language-targeted prehabilitation selectively changed language-network topography, while language and cognitive performance were preserved after the intervention. Key Findings Study type: a prehabilitation study using neuromodulation, language training, task-based functional MRI (fMRI), and neuropsychological testing. People studied: 26 patients with operable brain tumors affecting language …
