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TL;DR: A 2026 study in Nature Communications reported that tubulin redirected Tau and alpha-synuclein condensates toward microtubule-building states, while tubulin loss pushed the same protein system toward toxic oligomers in cell models. Key Findings 36-hour…
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TL;DR: A 2026 mouse and cell study in Nature found that developing neurons can generate DNA double-strand breaks while moving through narrow brain tissue during migration, then usually repair those breaks without cell death. Key Findings Developing neurons: Th…
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TL;DR: A 2026 protocol in JMIR Research Protocols describes EXCEL-PD, a randomized trial testing whether 26 weeks of virtually supervised home endurance and resistance exercise is feasible, safe, and biologically informative for people with Parkinson disease.…
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TL;DR: A 2026 study in Nature Communications found that proteotoxic stress can push neurons into karyoptosis, a cell-death pathway marked by nuclear lamina breakdown, nuclear-material expulsion, and dementia-linked tissue signatures. Key Findings Karyoptosis w…
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TL;DR: A 2026 ADNI analysis posted to medRxiv found that brain-derived plasma pTau217 better predicted near-term amyloid positron emission tomography (PET) positivity than total plasma pTau217 in cognitively unimpaired amyloid-negative participants. Key Findin…
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TL;DR: A 2026 retrospective analysis posted to medRxiv linked diclofenac and naproxen use in the NACC cohort to lower dementia and Alzheimer disease prevalence, while diclofenac use was also associated with slower Montreal Cognitive Assessment (MoCA) cognitive…
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TL;DR: A 2026 medRxiv preprint reported that peripheral blood RNA sequencing separated Parkinson disease from healthy controls and isolated REM sleep behavior disorder more clearly than it separated isolated REM sleep behavior disorder from controls. Key Findi…
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TL;DR: A 2026 protocol posted to medRxiv describes a nationwide Japan survey designed to measure how dementia specialists handle anti-amyloid antibody therapy, biomarker testing, MRI safety monitoring, service capacity, and patient-choice tradeoffs. Key Findin…
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TL;DR: A 2026 study in The Journal of Physiology found that steady-state Purkinje-cell firing patterns had limited ability to predict cerebellar nuclei output in mouse models of cerebellar movement disease. Key Findings 5 disease models: The reanalysis used in…
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TL;DR: A 2026 mouse study in Nature found that age-related gut microbiome changes impaired vagal gut-brain signaling and hippocampal memory encoding, while several interventions restored memory performance in aged or microbiome-aged mice. Key Findings Aged mic…
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