Neuropsychiatric Disorders

Resocialization After Social Isolation Reverses Neuroinflammation & Depression in Mice (2024 Study)

by

Resocialization significantly reduces depressive behaviors in socially isolated mice by decreasing neuroinflammation and nitrite levels in the hippocampus. Highlights: Depressive Behaviors: Resocialization reduced depressive behaviors in socially isolated mice, as shown by improved performance in behavioral tests. Neuroinflammation: Resocialization led to decreased levels of pro-inflammatory genes (IL-1β, TNF, and TLR4) in the hippocampus, indicating reduced …

Read more

Moderate Alcohol Intake Increases Depression Relapse in Men on SNRIs (2024 Study)

by

Moderate alcohol intake in men treated with SNRI antidepressants significantly increases the risk of depression relapse, according to a new study. Highlights: Risk Increase with SNRIs: Men with moderate alcohol consumption and elevated liver enzymes are significantly more likely to relapse when treated with serotonin-norepinephrine reuptake inhibitors (SNRIs). Sex Differences: Men generally had higher alcohol …

Read more

Aesthetic Chills (Frisson) May Help Treat Depression: Goosebumps from Emotional Stimuli (2024 Study)

by

Experiencing aesthetic chills can positively influence self-related beliefs in people with depression, similar to the effects of psychedelics, suggesting potential as a non-pharmacological intervention. Highlights: Novel Approach: Aesthetic chills, characterized by physical sensations like shivers and goosebumps, may help shift negative cognitive patterns in depression. Study Results: 96 patients with major depressive disorder showed positive …

Read more

Transcranial Alternating Current Stimulation (TACS) for Depression: Effective Adjunct via Reducing Prefrontal Alpha Waves (2024 Trial)

by

Adding transcranial alternating current stimulation (tACS) to antidepressant treatment improves depression symptoms more effectively than using antidepressants alone. Highlights: Enhanced Efficacy: tACS combined with antidepressants significantly reduces depression symptoms compared to antidepressant treatment alone. Lasting Effects: The additional antidepressant benefits of tACS persist for at least 4 weeks after treatment ends. Brain Activity Changes: Patients …

Read more

GLP-1 Receptor Agonists Like Semaglutide (Ozempic) May Treat Reward System Dysfunction (2024 Review)

by

GLP-1 receptor agonists (GLP-1RAs) show promise in regulating the reward system and potentially treating motivation and reward-processing disorders. Highlights: Regulation of Reward System Dysfunction: GLP-1RAs influence the brain’s reward system, which is involved in behaviors related to food and substance use. Brain Activation: These agonists affect brain regions differently in individuals ranging from lean to …

Read more

Lactofem Probiotic May Boost SSRI Efficacy & Counteract Sexual Side Effects in Women with Depression (2024 Trial)

by

Probiotics may help improve sexual function and reduce depression severity in women treated with SSRIs. Highlights: Depression Prevalence: Approximately 5% of all adults will experience depressive disorder, often accompanied by reduced sexual desire and dysfunction. Study Design: The study was a double-blind randomized clinical trial involving 112 women with depressive disorder treated with SSRIs, comparing …

Read more

Cancer-Related Suicide Trends in the U.S. (40-Year Analysis) (2024)

by

A comprehensive study of nearly 5 million cancer patients over 40 years revealed fluctuating trends in cancer-related suicides in the U.S., with a recent significant decrease likely due to advancements in psychosocial care and cancer treatment. Highlights: Data: Analyzed data from 4,870,410 cancer patients in the US between 1975 and 2017. Trend: Suicide rates increased …

Read more

Depression Linked to Topographic & Dynamic Reorganization of Global Brain Activity (2024)

by

Major depressive disorder (MDD) involves a topographic reorganization of brain activity from sensory to associative regions, affecting symptom co-occurrence through changes in neural dynamics and excitation-inhibition balance. Highlights: Topographic Reorganization: MDD patients show a shift in brain activity from unimodal sensory regions to transmodal associative regions. Neural Dynamics: This shift includes changes in the brain’s …

Read more

Epigenetic Biomarkers Predict Delirium Diagnosis: DNA Methylation Patterns (2024 Study)

by

Epigenetic markers, specifically DNA methylation (DNAm) differences, show promise as diagnostic tools for detecting delirium, including post-operative delirium (POD), across multiple patient cohorts. Highlights: Significant DNAm Differences: Analysis of blood samples from four independent cohorts identified significant DNAm differences between patients with and without delirium, with 11 of the top 13 CpG sites showing consistent …

Read more

Antidepressant Mechanisms of Aerobic Exercise (2024 Review)

by

Aerobic exercise reduces depressive symptoms by decreasing inflammation, boosting dopamine transmission, and enhancing motivation and cognitive control. Highlights: Depression & Dopamine: Depression is linked to disrupted dopamine transmission, affecting reward processing and motivation, particularly in effort-based decision-making. Inflammation’s Role: Exercise reduces systemic inflammation, which otherwise impairs dopamine transmission and contributes to depressive symptoms like anhedonia …

Read more

+ Load more