TL;DR: A 2026 pilot study in Food & Function found that one month of extra virgin olive oil intake was associated with higher resting-state occipital functional connectivity than regular olive oil in 9 healthy young adults. Key Findings Occipital connectivity was the imaging endpoint: The 9-person neuroimaging substudy came from a larger randomized crossover trial …
TL;DR: A 2026 mouse preprint in bioRxiv found that psilocybin reduced firing in somatostatin (SST) interneurons, inhibitory cortical cells that gate dendritic input, while increasing parvalbumin (PV) interneuron firing in the medial frontal cortex. Key Findings SST firing decreased: Opto-tagged SST interneurons fell from 5.5 to 3.7 Hz after psilocybin, while saline did not produce …
TL;DR: A 2026 systematic review and exploratory network meta-analysis of 5 randomized trials in Neurological Sciences found dose-specific ON-medication motor improvements, measured while usual Parkinson’s drugs were active, for some GLP-1 receptor agonists, glucose-related metabolic hormone drugs, in Parkinson’s disease, but broader motor, non-motor, and quality-of-life evidence remained limited. Key Findings 5 randomized trials: The …
TL;DR: A 2026 systematic review and meta-analysis in Neuropsychopharmacology found that dopamine D2-like receptor activation suppressed glucose-stimulated insulin secretion (GSIS), insulin release after high glucose, in animal pancreatic cells, suggesting one peripheral route by which antipsychotic dopamine blockade can disturb glucose control beyond weight gain. Key Findings 39 eligible studies: Researchers screened 12,457 citations and …
TL;DR: A 2025 scoping review in European Psychiatry screened 292 randomized trials of adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) and reported that 49.7% did not assess general psychopathology and only 35% had the ADHD diagnosis allocated by a psychiatrist or psychologist. Key Findings Half of the trials skipped a general psychopathology check: 49.7% of the …
TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the prefrontal cortex, and showed no rewarding or reinforcing properties at the tested doses. Key Findings Despair behavior fell after …
TL;DR: A 2026 medRxiv preprint found that targeted memory reactivation (TMR), replaying learned sounds during non-REM sleep, changed spindle and slow-wave density during a nap but did not improve motor memory retention in Parkinson’s disease or healthy older adults. Key Findings Parkinson’s and healthy older adults were compared: The experiment included 20 people with Parkinson’s …
TL;DR: A 2026 medRxiv preprint linked post-stroke depressive symptoms to stroke damage in serotonin-transporter and acetylcholine-transporter weighted brain networks, suggesting depression risk after stroke may depend partly on which neurochemical circuits a lesion disrupts. Key Findings 435 stroke patients analyzed: Researchers combined two independent cohorts, Leipzig and Oxford, after exclusions for missing clinical variables and …
TL;DR: A 2026 study in Translational Neurodegeneration found that reducing NDST3, a microtubule deacetylase that affects lysosome acidity, restored lysosomal acidification and reduced amyloid-beta and tau pathology in Alzheimer’s cell and mouse models. Key Findings Lysosomal pH shifted back: APP695Swe-overexpressing HT22 cells had lysosomal pH near 5.6, while Ndst3 knockdown lowered it to less than …
TL;DR: A 2026 study in Cognitive, Affective, & Behavioral Neuroscience found that image memorability, the stable tendency of an image to be remembered across people, predicted N400 brain responses at encoding even after later recognition success was modeled. Key Findings 24 analyzed participants: Researchers recorded event-related potentials (ERPs), scalp-measured brain responses time-locked to image viewing, …
