Phenibut Withdrawal Symptoms, Dependence, Dangers

Phenibut is a substance that acts on the brain and can cause dependence and addiction. Stopping phenibut suddenly after regular use leads to a withdrawal syndrome with potentially serious health consequences. What is Phenibut? Phenibut is a central nervous system depressant that was developed in Russia in the 1960s. It is used medically in some …

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Brainstem Volume Changes & Depression: Abnormalities in New & Recurrent Episodes

Researchers have discovered that changes in a region deep in the brain called the brainstem may contribute to recurring major depressive disorder (MDD). Key findings include: Patients with first-episode and recurrent depression showed volume decreases in brainstem regions like the pons and midbrain compared to healthy individuals. A region called the superior cerebellar peduncle (SCP) …

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Discovery of the 5-HTR1E Serotonin Receptor: Function & Importance in Brain Health

The neurotransmitter serotonin plays many important roles in our brains and bodies by binding to various serotonin receptor proteins. One of these receptors, called 5-HTR1E, has remained mysterious even after its discovery over 30 years ago. Facts about 5-HTR1E receptor: It is one of the 13 known serotonin receptor proteins that serotonin can bind to …

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Electroconvulsive Therapy (ECT) Long-Term Effects: Grey Matter Changes in the Brain

A new study tracked changes in brain volume in depressed patients after electroconvulsive therapy (ECT or “electroshock therapy”). The study found that ECT led to increases in gray matter (brain tissue), which then decreased substantially over the next 2 years. The initial increases did not relate to improvement in depression symptoms. However, greater decreases 2 …

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Understanding Critical Periods in Human Brain Development

The human brain goes through major changes as we grow from babies to adults. Scientists are interested in mapping out these changes to understand when and where the brain is most flexible to new experiences during development. Knowing when the brain is most flexible, called neuroplasticity, is important because experiences during these times have the …

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Chronic Stress & Drug Abuse: Overlapping Epigenetic Effects in the Brain

Experiencing chronic stress or taking addictive drugs like cocaine can change your brain and behavior in similar ways, making you prone to anxiety or addiction. Key Facts: Chronic stress and chronic drug abuse both impair the striatum, which can make people become rigid in their thinking and unable to update information. This can promote anxiety, …

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Type 2 Diabetes & Brain Effects in Native Americans: What A New Study Suggests

A new study looked at how having diabetes may impact brain health in Native Americans. The researchers found that the longer someone had diabetes, the more it affected their brain. But other health issues like obesity did not appear to impact the brain as much. Key facts: The study involved 51 Native Americans with type …

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Grin2a Gene Mutations in Mice Offer New Insights into Schizophrenia Causes and Treatment

Schizophrenia is a mental disorder that affects how people think, feel, and behave. It involves problems with hallucinations, delusions, disorganized thinking, lack of motivation, and impaired functioning. Schizophrenia affects about 1% of the population and typically starts in late adolescence or early adulthood. The causes are still poorly understood. In a new study, researchers found …

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