TL;DR: A 2026 review in Annals of Medicine argues that circadian rhythm disruption in major depressive disorder (MDD) reaches beyond poor sleep, linking clock-gene variation, sleep-wake timing, stress-hormone rhythms, melatonin signaling, and chronotherapy targets. Key Findings 264 million affected: The review frames MDD as a leading global disability cause affecting more than 264 million people. …
TL;DR: A 2026 Developmental Psychology randomized-trial follow-up found that children assigned to high-quality foster care after severe early deprivation had better adaptive functioning at age 18, especially in communication and socialization, than children who remained in care as usual. Key Findings Trial follow-up: The analysis used the Bucharest Early Intervention Project, a randomized trial comparing …
TL;DR: A 2025 medRxiv fMRI preprint linked higher apathy in both traumatic brain injury (TBI) and control groups to greater effort discounting, while TBI-related apathy was also associated with less exploratory decision-making and weaker neural encoding of differences between expected and received rewards. Key Findings 53-person fMRI sample: Researchers analyzed 34 people with chronic TBI …
TL;DR: A 2026 systematic review in Sports Medicine – Open found that esports gameplay can raise heart rate, stress physiology, and energy expenditure, but the overall metabolic demand generally stayed in the light-activity range. Key Findings 176 records screened: The review searched PubMed, Embase, SPORTDiscus, Web of Science, and Scopus before narrowing to 5 eligible …
TL;DR: A 2026 medRxiv preprint used functional MRI (fMRI) and complex harmonics decomposition to study mindfulness-based cognitive therapy in 80 people with major depressive disorder, reporting post-treatment changes in whole-brain manifolds during rumination. Key Findings 80-patient trial sample: The preprint analyzed fMRI data from a randomized controlled trial in major depressive disorder. MBCT plus TAU: …
TL;DR: A 2026 systematic review and meta-analysis in Archives of Women’s Mental Health linked prenatal active tobacco smoking with higher odds of postpartum depression, while secondhand smoke and electronic nicotine-product estimates were not statistically clear. Key Findings 29-study review: Researchers included 29 studies in the systematic review and 26 studies in the meta-analysis. 15% pooled …
TL;DR: A 2026 case-control study in Psychological Medicine linked major depressive disorder to faster blood-based transcriptomic aging and found that right-insula brain changes partly explained the depression association. Key Findings Transcriptomic aging was faster in depression: 141 people with major depressive disorder showed higher blood RNA-based aging acceleration than 134 healthy controls. The result strengthened …
TL;DR: A 2026 randomized trial in Molecular Autism found that a culturally adapted parent-implemented social communication program was linked to language, social-functioning, parent self-efficacy, and stress gains in Chinese-speaking autistic preschoolers, with no consistent advantage for therapist-led online groups over self-study across most outcomes. Key Findings Chinese preschoolers randomized: 112 autistic children aged 24-60 months …
TL;DR: A 2026 meta-analysis in PLOS One found clinically important sleep problems in refugee and asylum-seeking populations, with pooled sleep-adversity prevalence of 43.2% in adults and 36.4% in children and adolescents. Key Findings 66 studies reviewed: The systematic review and meta-analysis covered 42,956 refugees and asylum seekers. 43.2% adult prevalence: Pooled sleep-adversity prevalence in adults …
TL;DR: A 2026 study in Autism Research found that autistic children with early speech delay needed longer sound gaps to detect timing changes, but detected smaller pitch-frequency changes than typically developing peers. Key Findings 21 autistic children were compared with 23 typically developing children: The autism group had early language delay and early autistic manifestations, …
