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TL;DR: A 2026 study in NEJM Evidence found that solriamfetol added 9.4 minutes of objective wakefulness in early-morning shift work disorder after 4 weeks, without a higher overall adverse-event rate than placebo. Key Findings 78 early-morning workers: Partici…
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TL;DR: A 2026 study in Journal of Clinical Sleep Medicine found that in 65 continuous positive airway pressure (CPAP) adherent patients with obstructive sleep apnea, those who still showed objective daytime sleepiness on a psychomotor vigilance task scored wor…
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TL;DR: A 2026 MRI study in Brain Imaging and Behavior of 136 healthy young adults found no robust whole-brain gray matter, white matter, cortical thickness, or brain-age differences between early and late chronotypes. Key Findings 136 young adults: The study c…
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TL;DR: A 2026 network analysis study in European Archives of Psychiatry and Clinical Neuroscience found that insomnia was present in 18.3% and childhood trauma in 49.5% of patients, while daytime dysfunction and sleep-related distress were central nodes, while…
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TL;DR: A 2025 randomized trial in Scandinavian Journal of Primary Health Care found that a self-help book based on cognitive behavioral therapy for insomnia (CBT-I), a structured non-drug insomnia treatment, reduced daily hypnotic sleep-medication use and anxi…
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TL;DR: A 2026 medRxiv preprint found that targeted memory reactivation (TMR), replaying learned sounds during non-REM sleep, changed spindle and slow-wave density during a nap but did not improve motor memory retention in Parkinson’s disease or healthy older a…
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TL;DR: A 2026 mouse study in Psychopharmacology found that repeated dexamethasone, a synthetic glucocorticoid steroid, disrupted light-phase sleep and increased orexin-neuron activity, a wake-promoting hypothalamic signal, during sleep-to-wake transitions. Key…
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TL;DR: A 2026 systematic review in Journal of Clinical Sleep Medicine found that cognitive behavioral therapy for insomnia (CBT-I), a structured behavioral sleep treatment, plus sleep medication improved chronic insomnia more than medication alone, but adding…
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TL;DR: A 2025 mouse study in Cell mapped a sleep-growth hormone circuit, showing how hypothalamic GHRH and somatostatin neurons coordinate hormone pulses and then feed back onto wakefulness. Key Findings GH rose in REM and NREM: Growth hormone release was enha…
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TL;DR: A 2026 study in JAMA Network Open tracked 1,338 older adults from the Rush Memory and Aging Project for up to 19 years using objective wrist-actigraphy and found that each additional hour of daytime napping per day was linked to ~13% higher mortality, e…
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