RF Capsulotomy and ITP-DBS Ranked Highest for Refractory OCD

by
RF Capsulotomy and ITP-DBS Ranked Highest for Refractory OCD

TL;DR: A 2026 study in Molecular Psychiatry found that radiofrequency capsulotomy and inferior thalamic peduncle deep brain stimulation were associated with the largest symptom improvements among surgical strategies for refractory obsessive-compulsive disorder. Key Findings 75 studies: The network meta-analysis included 75 studies, 1,259 patients, and 20 surgical strategies for refractory obsessive-compulsive disorder. Y-BOCS was primary: …

Read more

Focused Ultrasound and rTMS Had Similar Stroke Motor Endpoints

by
Focused Ultrasound and rTMS Had Similar Stroke Motor Endpoints

TL;DR: A 2026 secondary analysis in PLOS One found that low-intensity focused ultrasound and repetitive transcranial magnetic stimulation (rTMS) had similar short-term post-stroke motor endpoint scores, while change-from-baseline Fugl-Meyer gains were larger with focused ultrasound. Key Findings 50-person comparison: The analysis compared 25 subacute stroke patients assigned to LIFU with 25 assigned to rTMS. 10 …

Read more

Hyperglycosylation Linked Glucosamine to Faster Alzheimer Progression

by
Hyperglycosylation Linked Glucosamine to Faster Alzheimer Progression

TL;DR: A 2026 study in Nature Metabolism identified brain hyperglycosylation as a metabolic driver of Alzheimer disease in human tissue and mouse models, while glucosamine exposure was linked to worse outcomes in Alzheimer-related dementia records. Key Findings Human AD brains showed excess glycans: Spatial glycomics found elevated N-glycan abundance in Alzheimer frontal cortex samples compared …

Read more

HEALing Communities Study Found Coalition Factors Behind OUD Implementation

by
HEALing Communities Study Found Coalition Factors Behind OUD Implementation

TL;DR: A 2026 study in Implementation Science Communications found that high-performing HEALing Communities Study coalitions used representative membership, shared goals, data support, and communications campaigns to strengthen opioid-use-disorder service implementation. Key Findings 8 communities studied: Researchers selected the top-performing urban and rural waitlist-control communities from each of four HEALing Communities Study sites. 41 interviews analyzed: …

Read more

Substance Use Disorders Affected 162.86 Million People Globally in 2021

by
Substance Use Disorders Affected 162.86 Million People Globally in 2021

TL;DR: A 2026 Journal of Global Health analysis of Global Burden of Disease 2021 data estimated that 162.86 million people had substance use disorders in 2021, with age-standardized rates down since 1990 but major inequality across sex, age, region, and development level. Key Findings 162.86 million cases: Global Burden of Disease 2021 estimates put worldwide …

Read more

Glioblastoma Long-Read Single-Cell Sequencing Found Tumor-Specific Isoforms

by
Glioblastoma Long-Read Single-Cell Sequencing Found Tumor-Specific Isoforms

TL;DR: A 2026 Nature Communications study used long-read single-cell RNA sequencing to map full-length isoforms in glioblastoma and found tumor-specific transcripts that short-read methods often miss. Key Findings 27 GBM samples: Researchers profiled histologically confirmed IDH-wildtype glioblastoma samples using matched short-read and long-read single-cell sequencing. 100 million reads: The optimized long-read workflow produced a median …

Read more

rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

by
rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

TL;DR: A 2026 randomized controlled study in Pakistan Journal of Pharmaceutical Sciences found that adding 20 Hz repetitive transcranial magnetic stimulation (rTMS) to risperidone was linked with lower cognitive-factor and aggression scores after 4 weeks in schizophrenia patients. Key Findings Schizophrenia trial sample: The single-center trial randomized 80 patients, with 40 assigned to risperidone alone …

Read more

GPR3 Linked CREB Signaling to Presynaptic Maturation

by
GPR3 Linked CREB Signaling to Presynaptic Maturation

TL;DR: A 2026 cellular neuroscience study in iScience found that GPR3, a constitutively active G-protein-coupled receptor, behaved like an immediate-early gene and helped connect CREB signaling to presynaptic maturation during neuronal differentiation. Key Findings Biphasic GPR3 induction: Gpr3 rose quickly after nerve growth factor stimulation, dipped, then increased again during later neuronal differentiation. NET-CAGE promoter …

Read more

GLP-1 Agonists Reduced Fat Mass With Modest Lean-Mass Loss

by
GLP-1 Agonists Reduced Fat Mass With Modest Lean-Mass Loss

TL;DR: A 2026 systematic review and meta-analysis in International Journal of Obesity found that glucagon-like peptide-1 receptor agonists, metabolic drugs that extend a satiety and glucose-control hormone pathway, reduced body weight mainly through fat loss while lean-mass reductions were generally modest. Key Findings 36 studies reviewed: Researchers included 36 studies in the qualitative review and …

Read more

Depression and Alcohol Polygenic Scores Improved Comorbidity Prediction

by
Depression and Alcohol Polygenic Scores Improved Comorbidity Prediction

TL;DR: A 2026 study in Behavior Genetics found that combining major depressive disorder and alcohol use disorder polygenic scores improved prediction of their comorbidity in 7,965 Add Health participants, but added little for either condition alone. Key Findings Add Health dataset anchored the analysis: The study used 7,965 European, African, and Admixed American ancestry participants …

Read more

+ Load more