TL;DR: A 2026 randomized trial in Archives of Disease in Childhood: Fetal and Neonatal Edition found that extended caffeine therapy reduced intermittent hypoxia, brief repeated oxygen-desaturation episodes, in very preterm infants through 41 weeks postmenstrual age. Key Findings 160 infants randomized: The ICAF trial assigned 78 infants to placebo and 82 infants to extended caffeine …
TL;DR: A 2026 placebo-controlled study in Human Psychopharmacology: Clinical and Experimental found that ebselen did not meaningfully reduce motor impulsivity, reflection impulsivity, delay discounting, or emotion-recognition outcomes in 130 healthy adults. Key Findings 130 adults analyzed: The double-blind study compared 66 adults assigned to ebselen with 64 assigned to placebo. 1800 mg over 2 days: …
TL;DR: A 2026 study in European Journal of Psychotraumatology found that 3 days of Community Resiliency Model (CRM) training, a body-based trauma-regulation skills program, improved compassion, social cohesion, forgiveness, and resilience among 152 Rwandan genocide survivors, released perpetrators, and mixed survivor-perpetrator groups. Key Findings Three groups completed CRM training: Researchers studied 51 genocide survivors, 51 …
TL;DR: A 2026 study in Psychological Medicine found that cognitive reserve in non-affective first-episode psychosis was higher with greater genetic predisposition to educational attainment and lower with earlier psychosis onset or family history of psychosis. Key Findings 174 first-episode patients: Researchers analyzed people with non-affective first-episode psychosis, with a mean age of 25.5 years. Educational-attainment …
TL;DR: A 2026 review in Current Opinion in Psychiatry found that earlier clozapine use in schizophrenia, especially after early nonresponse or relapse, was linked to better relapse prevention and stronger response rates than repeated nonclozapine antipsychotic trials. Key Findings Relapse prevention improved: Switching to clozapine after first relapse was associated with a 34% lower subsequent …
TL;DR: A 2026 mouse study in Neurochemical Research found that 28 days of unpredictable chronic mild stress increased dopamine D1 receptor binding across the striatum and raised dopamine D2 receptor binding only in selected regions, regardless of fatty acid-binding protein 7 gene deletion. Key Findings Adult male mice were exposed to 28 days of unpredictable …
TL;DR: A 2026 Phase I study in CNS Drugs found that a 400 mg powdered cannabidiol (CBD) formulation reached peak blood levels faster than oil-based Epidyolex, especially after a high-fat meal, while both products were generally well tolerated in healthy adults. Key Findings Four-way crossover trial: Researchers gave 32 healthy adults single 400 mg doses …
TL;DR: A 2026 study in Biochemistry and Biophysics Reports found that cannabinoid receptor 1 (CB1R) undergoes autophagy-linked degradation in mouse cortical neurons, but p62 deficiency did not make CB1R the main driver of obesity and low activity in p62 knockout mice. Key Findings CB1R accumulated up to 10-fold: Blocking autophagic flux with Bafilomycin A1 in …
TL;DR: A 2026 study in Nature Communications found that different brain-connectivity measures predicted different parts of associative learning: functional connectivity predicted acquisition, structural connectivity predicted extinction learning, and effective connectivity was most informative for renewal. Key Findings 509 resting-state fMRI scans: Researchers analyzed resting-state functional MRI data from 509 participants across six learning studies. 463 …
TL;DR: A 2026 Research Square preprint linked DNA methylation (DNAm), an epigenetic mark measured in cord blood at birth, with default mode network-limbic brain development and age-13 anxiety symptoms in boys. Key Findings Birth-to-teen pathway tested: Researchers analyzed 97 children from the GUSTO birth cohort who had cord-blood DNAm, repeated resting-state functional MRI (fMRI) scans, …
