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PCSK9 inhibitors significantly reduce the risk of amyotrophic lateral sclerosis (ALS) but increase the risk of Parkinson’s disease (PD). Highlights: ALS Risk Reduction: PCSK9 inhibitors marginally reduced the risk of ALS with an odds ratio of 0.89 (p = 0.048).…
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Repurposing general anesthetic drugs like ketamine for the treatment of major depression represents a significant medical advancement – showcasing rapid and sustained antidepressant effects. Highlights: Rapid Antidepressant Effects: Ketamine, nitrous oxide, pr…
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A Mendelian randomization study identified five gut microbiota taxa with potential causal effects on multiple sclerosis (MS), highlighting new avenues for understanding and treating the disease. Highlights: Causal Associations Identified: The study identified…
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This study examined how family health, perceived relationship quality, and attitudes toward childbearing are interconnected in Iranian women using the WHO model, finding that better family health and relationship quality positively influence childbearing attit…
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Adversity accelerates biological aging through health-compromising behaviors like smoking and possibly social disconnection, and future research needs to focus on causal methodologies to better understand these processes and develop effective interventions. Hi…
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Different psychiatric conditions exhibit varied sleep problems, with insomnia and fatigue being the most common issues. Highlights: Worst Sleep Profiles: Traits related to affect disorders, generalized anxiety, and ADHD show the worst sleep problems, including…
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Repetitive transcranial magnetic stimulation (rTMS) on the left dorsolateral prefrontal cortex (dlPFC) improves decision-making and reduces cravings in individuals with methamphetamine use disorder (MUD). Highlights: Improved Decision-Making: rTMS treatment en…
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Hypertension in older adults leads to poorer cognitive and walking performance due to the need for more brain resources to manage dual tasks. Highlights: Older adults with hypertension show higher brain activation in motor and sensory areas when performing dua…
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This study shows that type 2 diabetes causes decreased blood flow and changes in neural activity in specific parts of the hippocampus, which may initially compensate for cognitive decline but deteriorate with worsening diabetes. Highlights: Decreased Perfusion…
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The study found that higher levels of brain-derived neurotrophic factor (BDNF) and better cognitive function reduce suicidal thoughts in first-episode schizophrenia patients, while more severe symptoms and higher total cholesterol levels increase the risk. Hig…
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