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TL;DR: In 149 people with memory problems or dementia, blood levels of some brain markers tracked spinal fluid levels well, but others did not match at all. Two common measures of a leaky blood-brain barrier also did not agree with each other. Key Findings Blo…
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TL;DR: A 2026 preprint in medRxiv analyzed plasma proteomics in Alzheimer’s disease and mild cognitive impairment and found that four continuous molecular axes described the data better than hard subtype labels. Key Findings 5,895-person AD/MCI sample: The dis…
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TL;DR: A 2026 preprint posted on medRxiv reported that resting-state electroencephalography (EEG) neural slowing after stroke tracked secondary thalamic degeneration measured on structural MRI, even though the sampled patients did not have direct thalamic lesi…
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TL;DR: A 2026 protocol in JMIR Research Protocols describes EXCEL-PD, a randomized trial testing whether 26 weeks of virtually supervised home endurance and resistance exercise is feasible, safe, and biologically informative for people with Parkinson disease.…
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TL;DR: A 2026 medRxiv preprint reported that peripheral blood RNA sequencing separated Parkinson disease from healthy controls and isolated REM sleep behavior disorder more clearly than it separated isolated REM sleep behavior disorder from controls. Key Findi…
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TL;DR: A 2026 methodology paper in European Archives of Psychiatry and Clinical Neuroscience describes EMBER-MDD, a research-only multi-omic study designed to find treatment-resistance and esketamine-response biomarkers in about 420 adults with major depressiv…
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TL;DR: A 2026 preprint in medRxiv used amyloid positron-emission tomography, tau molecular imaging, and structural MRI to build individualized Alzheimer’s disease biomarker axes from ADNI and validate them in OASIS. Key Findings 12,430 ADNI images: The pipelin…
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TL;DR: A 2026 review in Neuropsychiatric Disease and Treatment argued that electroacupuncture (EA), acupuncture delivered with small electrical stimulation, has depression-related mechanism evidence, but clinical trials need biomarker-guided patient groups, st…
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TL;DR: A 2026 biomarker analysis in Brain, Behavior, & Immunity – Health across antidepressant trials found that kynurenine pathway metabolites were elevated in inflammatory depression compared with non-inflammatory depression and healthy controls, while omega…
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TL;DR: A 2026 preprint deep brain stimulation biomarker study in medRxiv found that home-recorded electrophysiology biomarkers tracked stable depression recovery during SCC DBS, while the biomarkers helped distinguish recovery from nonspecific symptom fluctuat…
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