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TL;DR: A 2026 systematic review and meta-analysis in Bipolar Disorders found that poor medication adherence in bipolar disorder was linked to substance use, psychotic features, lower insight, poorer functioning, and several markers of more severe illness, but…
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TL;DR: A 2026 systematic review and meta-analysis in Brain, Behavior, & Immunity – Health found that adding celecoxib to antidepressants was linked to lower depressive symptom scores in 7 small trials, but the efficacy evidence was rated very low certainty. Ke…
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TL;DR: A 2026 meta-analysis in Journal of Medical Internet Research did not find a statistically significant reduction in Patient Health Questionnaire-9 (PHQ-9) depression scores with AI-driven chatbots, but emotionally responsive, structured, and frequent int…
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TL;DR: A 2026 systematic review and meta-analysis in Pain Medicine found that Medicaid enrollment and preoperative benzodiazepine use had the largest pooled associations with new persistent opioid use after surgery among opioid-naive US adults. Key Findings 27…
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TL;DR: A 2026 meta-analysis in BMC Psychiatry found a moderate cross-sectional association between body dysmorphic disorder symptoms and perfectionism across 34 studies and 13,107 participants. Key Findings 34-study meta-analysis: The review pooled 34 studies…
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TL;DR: A 2026 systematic review and meta-analysis in BMC Psychiatry reported that olanzapine produced a numerically higher body mass index gain in anorexia nervosa trials, but the pooled randomized evidence remained small, heterogeneous, and not statistically…
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TL;DR: A 2026 systematic review and meta-analysis in Journal of Sleep Research found that agomelatine modestly improved subjective sleep quality versus placebo, but objective total sleep time did not significantly increase and somnolence reports were more freq…
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TL;DR: A 2026 meta-analysis in Psychological Medicine found that reduced resting-state connectivity between the amygdala and anterior cingulate cortex was the most robust brain-network difference in anxiety disorders. Key Findings 15 datasets: The meta-analysi…
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TL;DR: A 2026 systematic review and meta-analysis in Lupus found that psychosis affected about 4.5% of adults with systemic lupus erythematosus (SLE), was more common in neuropsychiatric SLE, and tracked most strongly with active immune disease markers rather…
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TL;DR: A 2026 systematic review and meta-analysis in European Journal of Psychotraumatology found that phase-based therapy was not clearly better than non-phase-based therapy for most complex PTSD outcomes, although multi-phase treatment had stronger PTSD effe…
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