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TL;DR: Researchers used wrist trackers to estimate the sleep stages of 95,559 British adults, then followed their hospital records for about 9 years. Adults who spent more time in REM sleep had lower risk of 83 different diagnoses, and adults sleeping under 5…
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TL;DR: A 2026 preprint in medRxiv analyzed plasma proteomics in Alzheimer’s disease and mild cognitive impairment and found that four continuous molecular axes described the data better than hard subtype labels. Key Findings 5,895-person AD/MCI sample: The dis…
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TL;DR: A 2026 Molecular Psychiatry study tested Regional Vulnerability Index for Alzheimer’s disease (RVI-AD), a structural-MRI score of how closely a person’s brain pattern resembles amyloid-positive Alzheimer’s disease, and found that higher RVI-AD predicted…
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TL;DR: A 2026 preprint UK Biobank neuroimaging study in medRxiv found that the comorbidity group showed widespread lower cortical volume, subcortical differences, and white matter microstructure alterations, while several alterations appeared unique to the chr…
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TL;DR: A 2026 BMC Medicine study of UK Biobank adults linked adversity in both childhood and adulthood to higher frailty, older metabolomic age profiles, lower grip strength, and some telomere differences, with the clearest associations in people reporting mul…
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TL;DR: A 2025 Molecular Psychiatry study of more than 36,000 people found that higher autism polygenic risk was associated with lower MRI-derived neurite density, a measure of neural-fiber packing, across cortex and white matter in both children and adults. Ke…
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Vigorous Activity Linked to Lower Dementia Risk in UK Biobank TL;DR: In UK Biobank accelerometer data, the vigorous share of daily movement accounted for 32% of dementia’s population-attributable fraction versus just 8% for total activity volume — suggesting b…
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Fish Oil Supplements Aren’t the Villain TL;DR: A comprehensive review of the UK Biobank found that fish oil supplements show favorable associations with health outcomes—not harmful ones—contradicting recent alarming headlines about atrial fibrillation risk. Wh…
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Cigarette smoking and mental health problems often go hand-in-hand. But which one typically comes first? And how much does our genetic makeup contribute to this risky combo? New research examined these questions by analyzing long-term health data on over 300,0…
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