EXPLORE THE SCIENCE
TL;DR: A 2026 cross-sectional metabolomics study in Brain, Behavior, & Immunity – Health found that serum and cerebrospinal fluid (CSF) metabolite signatures differed in knee osteoarthritis and related to pain, fatigue, sleep, and pressure sensitivity, while C…
Read article
TL;DR: A 2026 Psychological Medicine meta-analysis of 109 studies linked parental severe mental illness, especially schizophrenia and bipolar disorder, to lower cognitive performance in offspring across IQ, language, memory, executive function, and general cog…
Read article
TL;DR: A 2026 case-series study in Translational Psychiatry tested delayed-release oral acetate from apple cider vinegar capsules in 11 young adults taking psychotropic medications and found high adherence, no product-related adverse events, microbiome shifts,…
Read article
TL;DR: A 2026 mouse study in Nature found that small-molecule glucagon-like peptide 1 receptor agonists (GLP-1RAs), obesity and diabetes drugs built around a glucose-linked hormone pathway, suppressed palatable-food intake through central amygdala neurons that…
Read article
TL;DR: A 2026 study in The Journal of Neuroscience found that listening to consonant chord progressions while looking at a live partner increased functional near-infrared spectroscopy (fNIRS), a scalp blood-flow measure, in social brain systems. Key Findings D…
Read article
TL;DR: A 2026 mouse study in Cell traced ketamine’s rapid antidepressant-like effect to mu-opioid receptors on somatostatin-positive interneurons in the medial prefrontal cortex. Low-dose multi-GPCR targeting reproduced ketamine-like effects in mice, but the e…
Read article
TL;DR: A 2025 rat study in The Journal of Neuroscience found that caudal granular insular cortex (CGIC) projections to primary somatosensory cortex (SI) were required for neuropathic pain behavior, while activating the same pathway produced allodynia, or pain…
Read article
TL;DR: A 2026 post-hoc analysis in International Clinical Psychopharmacology found that lurasidone 40 mg/day improved all 5 Positive and Negative Syndrome Scale (PANSS) symptom domains in acute schizophrenia over 6 weeks, with the largest effect on positive sy…
Read article
TL;DR: A 2026 biomarker analysis in Brain, Behavior, & Immunity – Health across antidepressant trials found that kynurenine pathway metabolites were elevated in inflammatory depression compared with non-inflammatory depression and healthy controls, while omega…
Read article
TL;DR: A 2026 mouse preprint in bioRxiv reported that small-molecule IGF1R inhibitors, drugs that block insulin-like growth factor 1 receptor signaling, protected several healthspan measures in aging mice, but the tested compounds also carried major safety and…
Read article